María Cecilia Margarita Hidalgo Tapia

Desde ORCID

• Aging Favors Calcium Activation of Ryanodine Receptor Channels from Brain Cortices and Hippocampi and Hinders Learning and Memory in Male Rats

  More, J., Finkelstein, J. P., Valdés, J. L., Hidalgo, C. & Bull, R.

  International Journal of Molecular Sciences, 26, 2101 doi:10.3390/ijms26052101

• Calcium release via IP3R/RyR channels contributes to the nuclear and mitochondrial Ca2+ signals elicited by neuronal stimulation

  Gleitze, S., Ramírez, O. A., Vega-Vásquez, I., Stephan, E., Bengtson, C. P., Paula-Lima, A., Bading, H. & Hidalgo, C.

  Biochemical and Biophysical Research Communications, 754, 151445 doi:10.1016/j.bbrc.2025.151445

• Ryanodine Receptor Mediated Calcium Release Contributes to Ferroptosis Induced in Primary Hippocampal Neurons by GPX4 Inhibition

  Gleitze, S., Ramírez, O. A., Vega-Vásquez, I., Yan, J., Lobos, P., Bading, H., Núñez, M. T., Paula-Lima, A. & Hidalgo, C.

  Antioxidants, 12, 705 doi:10.3390/antiox12030705

• Ryanodine receptor-mediated Ca2+ release and atlastin-2 GTPase activity contribute to IP3-induced dendritic Ca2+ signals in primary hippocampal neurons

  Ramírez, O. A., Córdova, A., Cerda, M., Lobos, P., Härtel, S., Couve, A. & Hidalgo, C.

  Cell Calcium, 96, 102399 doi:10.1016/j.ceca.2021.102399

• RyR-mediated Ca ²⁺ release elicited by neuronal activity induces nuclear Ca ²⁺ signals, CREB phosphorylation, and Npas4/RyR2 expression

  Lobos, P., Córdova, A., Vega-Vásquez, I., Ramírez, O. A., Adasme, T., Toledo, J., Cerda, M., Härtel, S., Paula-Lima, A. & Hidalgo, C.

  Proceedings of the National Academy of Sciences, 118 doi:10.1073/pnas.2102265118

• The calcium–iron connection in ferroptosis-mediated neuronal death

  Gleitze, S., Paula-Lima, A., Núñez, M. T. & Hidalgo, C.

  Free Radical Biology and Medicine, 175, 28-41 doi:10.1016/j.freeradbiomed.2021.08.231

• Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation

  García, F., Lobos, P., Ponce, A., Cataldo, K., Meza, D., Farías, P., Estay, C., Oyarzun-Ampuero, F., Herrera-Molina, R., Paula-Lima, A., Ardiles, Á. O., Hidalgo, C., Adasme, T. & Muñoz, P.

  Marine Drugs, 18, 335 doi:10.3390/md18060335

• <i>N</i> -Methyl- <scp>d</scp> -Aspartate Receptor Modulation by Nicotinamide Adenine Dinucleotide Phosphate Oxidase Type 2 Drives Synaptic Plasticity and Spatial Memory Impairments in Rats Exposed Pre- and Postnatally to Ethanol

  Plaza-Briceño, W., Estay, S. F., de la Fuente-Ortega, E., Gutiérrez, C., Sánchez, G., Hidalgo, C., Chávez, A. E. & Haeger, P. A.

  Antioxidants &amp; Redox Signaling, 32, 602-617 doi:10.1089/ars.2019.7787

• Noxious Iron–Calcium Connections in Neurodegeneration

  Núñez, M. T. & Hidalgo, C.

  Frontiers in Neuroscience, 13 doi:10.3389/fnins.2019.00048

• Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory

  More, J. Y., Bruna, B. A., Lobos, P. E., Galaz, J. L., Figueroa, P. L., Namias, S., Sánchez, G. L., Barrientos, G. C., Valdés, J. L., Paula-Lima, A. C., Hidalgo, C. & Adasme, T.

  Antioxidants &amp; Redox Signaling, 29, 1125-1146 doi:10.1089/ars.2017.7277

• Contextual Fear Memory Formation and Destabilization Induce Hippocampal RyR2 Calcium Channel Upregulation

  More, J., Casas, M. M., Sánchez, G., Hidalgo, C. & Haeger, P.

  Neural Plasticity, 2018, 1-11 doi:10.1155/2018/5056181

• Mitochondrial Calcium Increase Induced by RyR1 and IP3R Channel Activation After Membrane Depolarization Regulates Skeletal Muscle Metabolism

  Díaz-Vegas, A. R., Cordova, A., Valladares, D., Llanos, P., Hidalgo, C., Gherardi, G., De Stefani, D., Mammucari, C., Rizzuto, R., Contreras-Ferrat, A. & Jaimovich, E.

  Frontiers in Physiology, 9 doi:10.3389/fphys.2018.00791

• N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer’s Disease Rat Model

  More, J., Galusso, N., Veloso, P., Montecinos, L., Finkelstein, J. P., Sanchez, G., Bull, R., Valdés, J. L., Hidalgo, C. & Paula-Lima, A.

  Frontiers in Aging Neuroscience, 10 doi:10.3389/fnagi.2018.00399

• Ryanodine Receptor-Mediated Calcium Release Has a Key Role in Hippocampal LTD Induction

  Arias-Cavieres, A., Barrientos, G. C., Sánchez, G., Elgueta, C., Muñoz, P. & Hidalgo, C.

  Frontiers in Cellular Neuroscience, 12 doi:10.3389/fncel.2018.00403

• The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K

  Bruna, B., Lobos, P., Herrera-Molina, R., Hidalgo, C., Paula-Lima, A. & Adasme, T.

  Biochemical and Biophysical Research Communications, 505, 201-207 doi:10.1016/j.bbrc.2018.09.080

• Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats

  Arias-Cavieres, A., More, J., Vicente, J. M., Adasme, T., Hidalgo, J., Valdés, J. L., Humeres, A., Valdés-Undurraga, I., Sánchez, G., Hidalgo, C. & Barrientos, G.

  Frontiers in Molecular Neuroscience, 11 doi:10.3389/fnmol.2018.00429

• Development of an iron-selective antioxidant probe with protective effects on neuronal function

  García-Beltrán, O., Mena, N. P., Aguirre, P., Barriga-González, G., Galdámez, A., Nagles, E., Adasme, T., Hidalgo, C. & Núñez, M. T.

  PLOS ONE, 12, e0189043 doi:10.1371/journal.pone.0189043

• Increased Hippocampal Expression of the Divalent Metal Transporter 1 (DMT1) mRNA Variants 1B and +IRE and DMT1 Protein After NMDA-Receptor Stimulation or Spatial Memory Training

  Haeger, P., Álvarez, Á., Leal, N., Adasme, T., Núñez, M. T. & Hidalgo, C.

  Neurotoxicity Research, 17, 238-247 doi:10.1007/s12640-009-9096-z