Jimena Alejandra Sierralta Jara
Profesora Titular
Doctora en Ciencias, Universidad de Chile, 1996
Áreas de investigación
Centros y afiliación
- Laboratorio de Neurobiología celular y molecular, Facultad e Medicina, Ude Chile
- Instituto de Neurociencia Biomédica
En mi laboratorio investigamos cómo se regula el metabolismos cerebral dependiendo de la actividad cerebral, usando el modelo animal Drosophila melanogaster y técnicas de neurobiología celular, molecular y genética. Además estudiamos la fisiología celular de la sinapsis mediante el uso de sensores codificados genéticamente in vivo. Más recientemente hemos incursionado en el estudio del eje intestino cerebro y el papel de los transportadores de lactato para la sobrevida y metástasis de los tumores cerebrales de tipo glioma.
Seleccionadas
Desde ORCID
Starvation Induces Upregulation of Monocarboxylate Transport in Glial Cells at the <i>Drosophila</i> Blood–Brain Barrier
González‐Gutiérrez, A., Gaete, J., Esparza, A., Ibacache, A., Contreras, E. G. & Sierralta, J.
Glia, 73, 1608-1626 doi:10.1002/glia.70021
The Inhibitory Effects of the Natural Stilbene Piceatannol on Lactate Transport In Vitro Mediated by Monocarboxylate Transporters
Ibacache‐Chía, A. P., Sierralta, J. A. & Schüller, A.
Molecular Nutrition & Food Research, 68 doi:10.1002/mnfr.202400414
A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer’s disease models
Xu, D., Vincent, A., González-Gutiérrez, A., Aleyakpo, B., Anoar, S., Giblin, A., Atilano, M. L., Adams, M., Shen, D., Thoeng, A., Tsintzas, E., Maeland, M., Isaacs, A. M., Sierralta, J. & Niccoli, T.
PLOS Genetics, 19, e1010893 doi:10.1371/journal.pgen.1010893
Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling
Bertin, F., Jara-Wilde, J., Auer, B., Köhler-Solís, A., González-Silva, C., Thomas, U. & Sierralta, J.
Biological Research, 56 doi:10.1186/s40659-023-00462-1
Identification of atlastin genetic modifiers in a model of hereditary spastic paraplegia in Drosophila
Candia, N., Ibacache, A., Medina-Yáñez, I., Olivares, G. H., Ramírez, M., Vega-Macaya, F., Couve, A., Sierralta, J. & Olguín, P.
Human Genetics, 142, 1303-1315 doi:10.1007/s00439-023-02577-7
Visualizing Monocarboxylates and Other Relevant Metabolites in the <em>Ex Vivo Drosophila</em> Larval Brain Using Genetically Encoded Sensors
González-Gutiérrez, A., Gaete, J., Esparza, A., Toledo, J., Köhler-Solis, A. & Sierralta, J.
Journal of Visualized Experiments doi:10.3791/65846
Dlg Is Required for Short-Term Memory and Interacts with NMDAR in the Drosophila Brain
Bertin, F., Moya-Alvarado, G., Quiroz-Manríquez, E., Ibacache, A., Köhler-Solis, A., Oliva, C. & Sierralta, J.
International Journal of Molecular Sciences, 23, 9187 doi:10.3390/ijms23169187
The Fly Blood-Brain Barrier Fights Against Nutritional Stress
Contreras, E. G. & Sierralta, J.
Neuroscience Insights, 17 doi:10.1177/26331055221120252
Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function
Medel, V., Crossley, N., Gajardo, I., Muller, E., Barros, L. F., Shine, J. M. & Sierralta, J.
Proceedings of the National Academy of Sciences, 119 doi:10.1073/pnas.2204619119
Editorial: Invertebrate Neuroscience: Contributions From Model and Non-model Species
Fernandez, M. P., Rittschof, C. C. & Sierralta, J. A.
Frontiers in Behavioral Neuroscience, 15 doi:10.3389/fnbeh.2021.726295
Erratum To: BAX inhibitor‐1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response
Castillo, K., Rojas‐Rivera, D., Lisbona, F., Caballero, B., Nassif, M., Court, F. A., Schuck, S., Ibar, C., Walter, P., Sierralta, J., Glavic, A. & Hetz, C.
The EMBO Journal, 40 doi:10.15252/embj.2021109149
Slit/Robo Signaling Regulates Multiple Stages of the Development of the Drosophila Motion Detection System
Guzmán-Palma, P., Contreras, E. G., Mora, N., Smith, M., González-Ramírez, M. C., Campusano, J. M., Sierralta, J., Hassan, B. A. & Oliva, C.
Frontiers in Cell and Developmental Biology, 9 doi:10.3389/fcell.2021.612645
The Serine Protease Homolog, Scarface, Is Sensitive to Nutrient Availability and Modulates the Development of the <i>Drosophila</i> Blood–Brain Barrier
Contreras, E. G., Glavic, Á., Brand, A. H. & Sierralta, J. A.
The Journal of Neuroscience, 41, 6430-6448 doi:10.1523/jneurosci.0452-20.2021
Neuronal lactate levels depend on glia‐derived lactate during high brain activity in Drosophila
González‐Gutiérrez, A., Ibacache, A., Esparza, A., Barros, L. F. & Sierralta, J.
Glia, 68, 1213-1227 doi:10.1002/glia.23772
Slit neuronal secretion coordinates optic lobe morphogenesis in Drosophila
Caipo, L., González-Ramírez, M. C., Guzmán-Palma, P., Contreras, E. G., Palominos, T., Fuenzalida-Uribe, N., Hassan, B. A., Campusano, J. M., Sierralta, J. & Oliva, C.
Developmental Biology, 458, 32-42 doi:10.1016/j.ydbio.2019.10.004
Novel Strategies for the Generation of Neuronal Diversity: Lessons From the Fly Visual System
Contreras, E. G., Sierralta, J. & Oliva, C.
Frontiers in Molecular Neuroscience, 12 doi:10.3389/fnmol.2019.00140
Chaski, a novel Drosophila lactate/pyruvate transporter required in glia cells for survival under nutritional stress
Delgado, M. G., Oliva, C., López, E., Ibacache, A., Galaz, A., Delgado, R., Barros, L. F. & Sierralta, J.
Scientific Reports, 8 doi:10.1038/s41598-018-19595-5
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α
Sepulveda, D., Rojas-Rivera, D., Rodríguez, D. A., Groenendyk, J., Köhler, A., Lebeaupin, C., Ito, S., Urra, H., Carreras-Sureda, A., Hazari, Y., Vasseur-Cognet, M., Ali, M. M., Chevet, E., Campos, G., Godoy, P., Vaisar, T., Bailly-Maitre, B., Nagata, K., Michalak, M., Sierralta, J. & Hetz, C.
Molecular Cell, 69, 238-252.e7 doi:10.1016/j.molcel.2017.12.028
p53 is required for brain growth but is dispensable for resistance to nutrient restriction during Drosophila larval development
Contreras, E. G., Sierralta, J. & Glavic, A.
PLOS ONE, 13, e0194344 doi:10.1371/journal.pone.0194344
The transcription factor SoxD controls neuronal guidance in the Drosophila visual system
Contreras, E. G., Palominos, T., Glavic, Á., Brand, A. H., Sierralta, J. & Oliva, C.
Scientific Reports, 8 doi:10.1038/s41598-018-31654-5
<i>Drosophila</i> Atlastin in motor neurons is required for locomotion and presynaptic function
De Gregorio, C., Delgado, R., Ibacache, A., Sierralta, J. & Couve, A.
Journal of Cell Science, 130, 3507-3516 doi:10.1242/jcs.201657
Presynaptic DLG regulates synaptic function through the localization of voltage-activated Ca2+ Channels
Astorga, C., Jorquera, R. A., Ramírez, M., Kohler, A., López, E., Delgado, R., Córdova, A., Olguín, P. & Sierralta, J.
Scientific Reports, 6 doi:10.1038/srep32132
Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex
Oliva, C., Soldano, A., Mora, N., De Geest, N., Claeys, A., Erfurth, M. L., Sierralta, J., Ramaekers, A., Dascenco, D., Ejsmont, R. K., Schmucker, D., Sanchez-Soriano, N. & Hassan, B. A.
Developmental Cell, 39, 267-278 doi:10.1016/j.devcel.2016.09.028
Hindsight regulates photoreceptor axon targeting through transcriptional control of <i>jitterbug/Filamin</i> and multiple genes involved in axon guidance in <scp><i>D</i></scp>rosophila
Oliva, C., Molina‐Fernandez, C., Maureira, M., Candia, N., López, E., Hassan, B., Aerts, S., Cánovas, J., Olguín, P. & Sierralta, J.
Developmental Neurobiology, 75, 1018-1032 doi:10.1002/dneu.22271
The Specification of Cortical Subcerebral Projection Neurons Depends on the Direct Repression of TBR1 by CTIP1/BCL11a
Cánovas, J., Berndt, F. A., Sepúlveda, H., Aguilar, R., Veloso, F. A., Montecino, M., Oliva, C., Maass, J. C., Sierralta, J. & Kukuljan, M.
The Journal of Neuroscience, 35, 7552-7564 doi:10.1523/jneurosci.0169-15.2015
How doth the little busy bee: unexpected metabolism
Barros, L. F., Sierralta, J. & Weber, B.
Trends in Neurosciences, 38, 1-2 doi:10.1016/j.tins.2014.11.005
Role of the maguk protein family in synapse formation and function
Oliva, C., Escobedo, P., Astorga, C., Molina, C. & Sierralta, J.
Developmental Neurobiology, 72, 57-72 doi:10.1002/dneu.20949
TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis
Rojas-Rivera, D., Armisén, R., Colombo, A., Martínez, G., Eguiguren, A. L., Díaz, A., Kiviluoto, S., Rodríguez, D., Patron, M., Rizzuto, R., Bultynck, G., Concha, M. L., Sierralta, J., Stutzin, A. & Hetz, C.
Cell Death & Differentiation, 19, 1013-1026 doi:10.1038/cdd.2011.189
BAX inhibitor‐1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response
Castillo, K., Rojas‐Rivera, D., Lisbona, F., Caballero, B., Nassif, M., Court, F. A., Schuck, S., Ibar, C., Walter, P., Sierralta, J., Glavic, A. & Hetz, C.
The EMBO Journal, 30, 4465-4478 doi:10.1038/emboj.2011.318
A Perisynaptic Ménage à Trois between Dlg,<i>D</i>Lin-7, and Metro Controls Proper Organization of Drosophila Synaptic Junctions
Bachmann, A., Kobler, O., Kittel, R. J., Wichmann, C., Sierralta, J., Sigrist, S. J., Gundelfinger, E. D., Knust, E. & Thomas, U.
The Journal of Neuroscience, 30, 5811-5824 doi:10.1523/jneurosci.0778-10.2010
Regulation of axonal development by the nuclear protein hindsight (pebbled) in the Drosophila visual system
Oliva, C. & Sierralta, J.
Developmental Biology, 344, 911-921 doi:10.1016/j.ydbio.2010.06.007
Endothelial Epithelial Sodium Channel Inhibition Activates Endothelial Nitric Oxide Synthase via Phosphoinositide 3-Kinase/Akt in Small-Diameter Mesenteric Arteries
Pérez, F. R., Venegas, F., González, M., Andrés, S., Vallejos, C., Riquelme, G., Sierralta, J. & Michea, L.
Hypertension, 53, 1000-1007 doi:10.1161/hypertensionaha.108.128520
Expression of voltage-activated calcium channels in the early zebrafish embryo
Sanhueza, D., Montoya, A., Sierralta, J. & Kukuljan, M.
Zygote, 17, 131-135 doi:10.1017/s0967199408005108
DLGS97/SAP97 Is Developmentally Upregulated and Is Required for Complex Adult Behaviors and Synapse Morphology and Function
Mendoza-Topaz, C., Urra, F., Barría, R., Albornoz, V., Ugalde, D., Thomas, U., Gundelfinger, E. D., Delgado, R., Kukuljan, M., Sanxaridis, P. D., Tsunoda, S., Ceriani, M. F., Budnik, V. & Sierralta, J.
The Journal of Neuroscience, 28, 304-314 doi:10.1523/jneurosci.4395-07.2008
Temporal and spatial expression of Drosophila DLGS97 during neural development
Albornoz, V., Mendoza-Topaz, C., Oliva, C., Tello, J., Olguín, P. & Sierralta, J.
Gene Expression Patterns, 8, 443-451 doi:10.1016/j.gep.2008.04.001
Erratum: Novel isoforms of dlg are fundamental for neuronal development in drosophila (Journal of Neuroscience (2003) (2093-2101))
Journal of Neuroscienceenlace
Cell type-specific recruitment of <i>Drosophila</i> Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97
Bachmann, A., Timmer, M., Sierralta, J., Pietrini, G., Gundelfinger, E. D., Knust, E. & Thomas, U.
Journal of Cell Science, 117, 1899-1909 doi:10.1242/jcs.01029
PDZ-containing proteins: alternative splicing as a source of functional diversity
Sierralta, J. & Mendoza, C.
Brain Research Reviews, 47, 105-115 doi:10.1016/j.brainresrev.2004.06.002
Novel Isoforms of Dlg Are Fundamental for Neuronal Development in<i>Drosophila</i>
Mendoza, C., Olguı́n, P., Lafferte, G., Thomas, U., Ebitsch, S., Gundelfinger, E. D., Kukuljan, M. & Sierralta, J.
The Journal of Neuroscience, 23, 2093-2101 doi:10.1523/jneurosci.23-06-02093.2003
Presence of Ca<sup>2</sup><sup>+</sup>-Dependent K<sup>+</sup>Channels in Chemosensory Cilia Support a Role in Odor Transduction
Delgado, R., Saavedra, M. V., Schmachtenberg, O., Sierralta, J. & Bacigalupo, J.
Journal of Neurophysiology, 90, 2022-2028 doi:10.1152/jn.01167.2002
A functional assay for paralytic shellfish toxins that uses recombinant sodium channels
Vélez, P., Sierralta, J., Alcayaga, C., Fonseca, M., Loyola, H., Johns, D., Tomaselli, G., Marbán, E. & Suárez-Isla, B.
Toxicon, 39, 929-935 doi:10.1016/s0041-0101(00)00230-0
Specificity in signaling pathways: assembly into multimolecular signaling complexes
Tsunoda, S., Sierralta, J. & Zuker, C. S.
Current Opinion in Genetics & Development, 8, 419-422 doi:10.1016/s0959-437x(98)80112-3
A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade
Tsunoda, S., Sierralta, J., Sun, Y., Bodner, R., Suzuki, E., Becker, A., Socolich, M. & Zuker, C. S.
Nature, 388, 243-249 doi:10.1038/40805
Functionally Heterogenous Ryanodine Receptors in Avian Cerebellum
Sierralta, J., Fill, M. & Suárez-Isla, B. A.
Journal of Biological Chemistry, 271, 17028-17034 doi:10.1074/jbc.271.29.17028
Modal gating in neuronal and skeletal muscle ryanodine-sensitive Ca2+ release channels
Armisen, R., Sierralta, J., Velez, P., Naranjo, D. & Suarez-Isla, B. A.
American Journal of Physiology-Cell Physiology, 271, C144-C153 doi:10.1152/ajpcell.1996.271.1.c144
Properties of the Ryanodine‐sensitive Release Channels that Underlie Caffeine‐induced Ca<sup>2+</sup>Mobilization from Intracellular Stores in Mammalian Sympathetic Neurons
Hernández‐Cruz, A., Díaz‐Muñoz, M., Gómez‐Chavarín, M., Canñedo‐Merino, R., Protti, D. A., Escobar, A. L., Sierralta, J. & Suárez‐Isla, B. A.
European Journal of Neuroscience, 7, 1684-1699 doi:10.1111/j.1460-9568.1995.tb00690.x
Characterization and Subcellular Distribution of G-Proteins in Highly Purified Skeletal Muscle Fractions from Rabbit and Frog
Carrasco, M., Sierralta, J. & Demazancourt, P.
Archives of Biochemistry and Biophysics, 310, 76-81 doi:10.1006/abbi.1994.1142
Phospholipase C activity in membranes and a soluble fraction isolated from frog skeletal muscle
Angélica Carrasco, M., Sierralta, J. & Hidalgo, C.
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1152, 44-48 doi:10.1016/0005-2736(93)90229-s
Effect of dopamine depletion upon the K+-evoked release of CCK from superfused striatal slices
Sierralta, J. & Gysling, K.
Neuroscience Letters, 112, 313-317 doi:10.1016/0304-3940(90)90222-u