Felipe Humberto Salech Morales

Profesor Asistente

Áreas de investigación

Envejecimiento y Neurodegeneración Neurología clínica y traslacional

Envejecimiento saludable y gerociencia; medicina preventiva; biología del envejecimiento (proteína Klotho y neurogénesis hipocampal del adulto); biomarcadores de envejecimiento cerebral saludable (‘súper ancianos’).

Formación

Médico geriatra. Doctor (PhD) — MD-PhD, U. de Chile.

Afiliación

Profesor encargado del Programa de Geriatría; Sección de Geriatría, Hospital Clínico U. de Chile; Depto. de Medicina Interna Norte; Depto. de Neurociencia; INTA; Centro de Investigación Clínica Avanzada (CICA). Investigador de GERO; Red Transdisciplinaria sobre Envejecimiento; UCAM, Clínica Las Condes.

Desde ORCID

Cancer History Avoids the Increase of Senescence Markers in Peripheral Cells of Amnestic Mild Cognitive Impaired Patients
SanMartín, C. D., Salech, F., Ponce, D. P., Concha-Cerda, J., Romero-Hernández, E., Liabeuf, G., Rogers, N. K., Murgas, P., Bruna, B., More, J. & Behrens, M. I.
International Journal of Molecular Sciences, 24, 7364 doi:10.3390/ijms24087364
Non-pharmacological prevention of postoperative delirium by occupational therapy teams: A randomized clinical trial
Alvarez, E. A., Rojas, V. A., Caipo, L. I., Galaz, M. M., Ponce, D. P., Gutierrez, R. G., Salech, F., Tobar, E., Reyes, F. I., Vergara, R. C., Egaña, J. I., Briceño, C. A. & Penna, A.
Frontiers in Medicine, 10 doi:10.3389/fmed.2023.1099594
Epidemiology of delirium in hospitalized patients in <scp>Latin America</scp> : A systematic review
Bravo, M., Bustos, S., Acuña, E., Cisternas, I., Gutierrez, P., Vega, D. P. P. D. L., Castro, R., Tobar, E., Maldonado, J. & Salech, F.
Acta Psychiatrica Scandinavica, 147, 420-429 doi:10.1111/acps.13468
Multiple events case–control study in a prospective cohort to identify systemic, cellular, and molecular biomarkers of obesity-induced accelerated aging in 30-years-olds: the ObAGE study protocol
Correa-Burrows, P., Burrows, R., Albala, C., Court, F., Salech, F., Sanhueza, G. & Gonzalez-Billault, C.
BMC Geriatrics, 22 doi:10.1186/s12877-022-03032-4
Pediatric Extracorporeal Membrane Oxygenation (ECMO) Transport in a Developing Nation: A Single Center Experience
Martinez, D., Diaz, R., Rufs, J., Fajardo, C., Valverde, C. & Salech, F.
ASAIO Journal, 68, e96-e98 doi:10.1097/mat.0000000000001567
Senescence Markers in Peripheral Blood Mononuclear Cells in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease
Salech, F., SanMartín, C. D., Concha-Cerda, J., Romero-Hernández, E., Ponce, D. P., Liabeuf, G., Rogers, N. K., Murgas, P., Bruna, B., More, J. & Behrens, M. I.
International Journal of Molecular Sciences, 23, 9387 doi:10.3390/ijms23169387
The effect of rapamycin and its analogues on age-related musculoskeletal diseases: a systematic review
Lin, H., Salech, F., Lim, A., Vogrin, S. & Duque, G.
Aging Clinical and Experimental Research, 34, 2317-2333 doi:10.1007/s40520-022-02190-0
A software to prevent delirium in hospitalised older adults: development and feasibility assessment
Alvarez, E. A., Garrido, M., Ponce, D. P., Pizarro, G., Córdova, A. A., Vera, F., Ruiz, R., Fernández, R., Velásquez, J. D., Tobar, E. & Salech, F.
Age and Ageing, 49, 239-245 doi:10.1093/ageing/afz166
Consolidated framework for advancing implementation science for the implementation process and adherence assessment of a non‐pharmacological delirium prevention program
Garrido, M. A., Alvarez, E. A., Ponce, D. P., Salech, F., Tobar, D. I. & Tobar, E. A.
International Journal of Geriatric Psychiatry, 36, 302-313 doi:10.1002/gps.5425
Fall Prevention in Community-Dwelling Older Adults
New England Journal of Medicine, 382, 2579-2582 doi:10.1056/nejmc2005662
Inverse Relationship Between Alzheimer’s Disease and Cancer: How Immune Checkpoints Might Explain the Mechanisms Underlying Age-Related Diseases
Rogers, N. K., Romero, C., SanMartín, C. D., Ponce, D. P., Salech, F., López, M. N., Gleisner, A., Tempio, F. & Behrens, M. I.
Journal of Alzheimer’s Disease, 73, 443-454 doi:10.3233/jad-190839
Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer’s Disease
Salech, F., Ponce, D. P., Paula-Lima, A. C., SanMartin, C. D. & Behrens, M. I.
Frontiers in Aging Neuroscience, 12 doi:10.3389/fnagi.2020.00255
Osteosarcopenia Predicts Falls, Fractures, and Mortality in Chilean Community-Dwelling Older Adults
Salech, F., Marquez, C., Lera, L., Angel, B., Saguez, R. & Albala, C.
Journal of the American Medical Directors Association, 22, 853-858 doi:10.1016/j.jamda.2020.07.032
Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus
Salech, F., Varela-Nallar, L., Arredondo, S. B., Bustamante, D. B., Andaur, G. A., Cisneros, R., Ponce, D. P., Ayala, P., Inestrosa, N. C., Valdés, J. L., I. Behrens, M. & Couve, A.
The Journals of Gerontology: Series A, 74, 1043-1051 doi:10.1093/gerona/glx248
Cancer Imprints an Increased PARP-1 and p53-Dependent Resistance to Oxidative Stress on Lymphocytes of Patients That Later Develop Alzheimer's Disease
Salech, F., Ponce, D. P., SanMartín, C. D., Rogers, N. K., Henríquez, M. & Behrens, M. I.
Frontiers in Neuroscience, 12 doi:10.3389/fnins.2018.00058
Vitamin D Increases Aβ140 Plasma Levels and Protects Lymphocytes from Oxidative Death in Mild Cognitive Impairment Patients
SanMartín, C. D., Henriquez, M., Chacon, C., Ponce, D. P., Salech, F., Rogers, N. K. & Behrens, M. I.
Current Alzheimer Research, 15, 561-569 doi:10.2174/1567205015666171227154636
PARP-1 and p53 Regulate the Increased Susceptibility to Oxidative Death of Lymphocytes from MCI and AD Patients
Salech, F., Ponce, D. P., SanMartín, C. D., Rogers, N. K., Chacón, C., Henríquez, M. & Behrens, M. I.
Frontiers in Aging Neuroscience, 9 doi:10.3389/fnagi.2017.00310
Tumor-induced osteomalacia: experience from a South American academic center
González, G., Baudrand, R., Sepúlveda, M. F., Vucetich, N., Guarda, F. J., Villanueva, P., Contreras, O., Villa, A., Salech, F., Toro, L., Michea, L. & Florenzano, P.
Osteoporosis International, 28, 2187-2193 doi:10.1007/s00198-017-4007-2
Frizzled-1 receptor regulates adult hippocampal neurogenesis
Mardones, M. D., Andaur, G. A., Varas-Godoy, M., Henriquez, J. F., Salech, F., Behrens, M. I., Couve, A., Inestrosa, N. C. & Varela-Nallar, L.
Molecular Brain, 9 doi:10.1186/s13041-016-0209-3
Increased susceptibility to oxidative death of lymphocytes from Alzheimer patients correlates with dementia severity.
Current Alzheimer researchenlace
Inverse Susceptibility to Oxidative Death of Lymphocytes Obtained From Alzheimer's Patients and Skin Cancer Survivors: Increased Apoptosis in Alzheimer's and Reduced Necrosis in Cancer
Behrens, M. I., Silva, M., Salech, F., Ponce, D. P., Merino, D., Sinning, M., Xiong, C., Roe, C. M. & Quest, A. F. G.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 67, 1036-1040 doi:10.1093/gerona/glr258
Age-Dependent Increases in Apoptosis/Necrosis Ratios in Human Lymphocytes Exposed to Oxidative Stress
Behrens, M. I., Silva, M., Schmied, A., Salech, F., Manzur, H., Rebolledo, R., Bull, R., Torres, V., Henriquez, M. & Quest, A. F. G.
The Journals of Gerontology: Series A, 66A, 732-740 doi:10.1093/gerona/glr039
Thalidomide for the treatment of metastatic hepatic epithelioid hemangioendothelioma: a case report with a long term follow-up.
Annals of hepatology
Measuring students' perceptions of the educational climate of the new curriculum at the Pontificia Universidad Católica de Chile: performance of the Spanish translation of the Dundee Ready Education Environment Measure (DREEM).
Education for health (Abingdon, England)
[Studies about diagnostic tests: interpreting the results].
Revista medica de Chile doi:/s0034-98872008000900018
Value of Adenosine Deaminase (ADA) in Ascitic Fluid for the Diagnosis of Tuberculous Peritonitis
Riquelme, A., Calvo, M., Salech, F., Valderrama, S., Pattillo, A., Arellano, M., Arrese, M., Soza, A., Viviani, P. & Letelier, L. M.
Journal of Clinical Gastroenterology, 40, 705-710 doi:10.1097/00004836-200609000-00009

Ver todas en ORCID →

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Felipe Humberto Salech Morales

Áreas de investigación

Formación

Afiliación

Desde ORCID

Cancer History Avoids the Increase of Senescence Markers in Peripheral Cells of Amnestic Mild Cognitive Impaired Patients

Non-pharmacological prevention of postoperative delirium by occupational therapy teams: A randomized clinical trial

Epidemiology of delirium in hospitalized patients in <scp>Latin America</scp> : A systematic review

Multiple events case–control study in a prospective cohort to identify systemic, cellular, and molecular biomarkers of obesity-induced accelerated aging in 30-years-olds: the ObAGE study protocol

Pediatric Extracorporeal Membrane Oxygenation (ECMO) Transport in a Developing Nation: A Single Center Experience

Senescence Markers in Peripheral Blood Mononuclear Cells in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease

The effect of rapamycin and its analogues on age-related musculoskeletal diseases: a systematic review

A software to prevent delirium in hospitalised older adults: development and feasibility assessment

Consolidated framework for advancing implementation science for the implementation process and adherence assessment of a non‐pharmacological delirium prevention program

Fall Prevention in Community-Dwelling Older Adults

Inverse Relationship Between Alzheimer’s Disease and Cancer: How Immune Checkpoints Might Explain the Mechanisms Underlying Age-Related Diseases

Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer’s Disease

Osteosarcopenia Predicts Falls, Fractures, and Mortality in Chilean Community-Dwelling Older Adults

Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus

Cancer Imprints an Increased PARP-1 and p53-Dependent Resistance to Oxidative Stress on Lymphocytes of Patients That Later Develop Alzheimer's Disease

Vitamin D Increases Aβ140 Plasma Levels and Protects Lymphocytes from Oxidative Death in Mild Cognitive Impairment Patients

PARP-1 and p53 Regulate the Increased Susceptibility to Oxidative Death of Lymphocytes from MCI and AD Patients

Tumor-induced osteomalacia: experience from a South American academic center

Frizzled-1 receptor regulates adult hippocampal neurogenesis

Increased susceptibility to oxidative death of lymphocytes from Alzheimer patients correlates with dementia severity.

Inverse Susceptibility to Oxidative Death of Lymphocytes Obtained From Alzheimer's Patients and Skin Cancer Survivors: Increased Apoptosis in Alzheimer's and Reduced Necrosis in Cancer

Age-Dependent Increases in Apoptosis/Necrosis Ratios in Human Lymphocytes Exposed to Oxidative Stress

Thalidomide for the treatment of metastatic hepatic epithelioid hemangioendothelioma: a case report with a long term follow-up.

Measuring students' perceptions of the educational climate of the new curriculum at the Pontificia Universidad Católica de Chile: performance of the Spanish translation of the Dundee Ready Education Environment Measure (DREEM).

[Studies about diagnostic tests: interpreting the results].

Value of Adenosine Deaminase (ADA) in Ascitic Fluid for the Diagnosis of Tuberculous Peritonitis