Christian Enrique González Billault

Desde ORCID

• Mitochondrial complex-derived ROS induces lysosomal dysfunction and impairs autophagic flux in human cells carrying the APOE4 allele

  Niño, S. A., Barrios-Camus, O., Silva-Pavez, E., Cárdenas, J. C. & González-Billault, C.

  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1872, 168211 doi:10.1016/j.bbadis.2026.168211

• NMDAR and glutamate control axon growth by regulating Rac1-dependent actin dynamics and H2O2 production

  Muñoz-Palma, E., Acosta-Tapia, N., Villablanca, C., Wilson, C., Hidalgo, C. & González-Billault, C.

  Redox Biology, 90, 104027 doi:10.1016/j.redox.2026.104027

• Plasma ATN biomarkers across the alzheimer’s disease continuum in a Chilean community- and clinic-based cohort

  Orellana, P., Henríquez, F., Cabral-Miranda, F., Hernandez, H., Ferreira, P. C. L., Bellaver, B., Caviedes, A., Pizarro, M., Gonzalez-Silva, C., Marin-Diaz, N., Riquelme, P., Pozo, N., Damm, F., Court, F. A., Gonzalez-Billault, C., Lillo, P., Thumala-Dockendorff, D., Cerda, M., Villagra, R., de la Cruz, R., Karikari, T., Ibañez, A. & et al.

  Alzheimer's Research & Therapy, 18 doi:10.1186/s13195-026-01974-0

• Reticulon-1 synthesis controls outgrowth and microtubule dynamics in injured cortical axons

  Luarte, A., Gallardo, J., Corvalán, D., Chakraborty, A., Gouveia Roque, C., Bertin, F., Contreras, C., Ramírez, J. P., Weber, A., Acevedo, W., Zuschratter, W., Herrera-Molina, R., Wyneken, Ú., Paula-Lima, A., Adasme-Rocha, T., Toledo, J., Vergara, R., Figueroa, A., González, C., González-Billault, C., Hengst, U. & Couve, A.

  Life Science Alliance, 9, e202503571 doi:10.26508/lsa.202503571

• The neuroactive potential of the elderly human gut microbiome is associated with mental health status

  Calderón-Romero, P., Valderrama, B., Bastiaanssen, T. F. S., Lillo, P., Thumala-Dockendorff, D., Clarke, G., Cryan, J. F., Slachevsky, A., González-Billault, C. & Court, F. A.

  PLOS One, 21, e0343493 doi:10.1371/journal.pone.0343493

• Calcium (Ca2+) fluxes at mitochondria-ER contact sites (MERCS) are a new target of senolysis in therapy-induced senescence (TIS)

  Puebla-Huerta, A., Huerta, H., Quezada-Gutierez, C., Morgado-Cáceres, P., Casanova-Canelo, C., Niño, S. A., Linsambarth, S., Díaz-Rivera, O., López-Domínguez, J. A., Rodríguez-López, S., González-Reyes, J. A., Bustos, G., Silva-Pavez, E., Lovy, A., Quiroz, G., González-Seguel, C., Salas-Huenuleo, E., Kogan, M. J., Molgó, J., Zakarian, A., Villalba, J. M., Gonzalez-Billault, C. & et al.

  npj Aging, 11 doi:10.1038/s41514-025-00197-1

• Doxorubicin Induces a Senescent Phenotype in Murine and Human Astrocytes

  Marques, M., Hayashide, L. D. S., Amorim, P., Fernandes, B. M., Araujo, A. P. B., Messor, D. F., Leocadio, V. E., Pessoa, B., Corrêa, J. B. L. P., Villablanca, C., Vidal, R. L., González‐Billault, C., Matias, I., Gomes, F. C. A. & Diniz, L. P.

  Journal of Neurochemistry, 169 doi:10.1111/jnc.70177

• Impact of cardiometabolic factors and AD plasma biomarkers on white matter hyperintensities volume in individuals with cognitive complaints from the global south

  Riquelme-Contreras, P., Henriquez, F., Gonzalez-Campo, C., Altschuler, F., Fraile-Vazquez, M., Ferreira, P. C., Bellaver, B., Karikari, T. K., Pascoal, T. A., Okuma, C., Gonzalez-Billault, C., Court, F. A., Cerda, M., Lillo, P., Durán-Aniotz, C., Khondoker, M., Hornberger, M. & Slachevsky, A.

  Neuroscience, 595, 270-279 doi:10.1016/j.neuroscience.2025.11.013

• Long-Term Obesity and Biological Aging in Young Adults

  Correa-Burrows, P., Burrows, R., Albala, C., Sepúlveda, C., Salech, F., Troncoso, R., Bunout, D. & Gonzalez-Billault, C.

  JAMA Network Open, 8, e2520011 doi:10.1001/jamanetworkopen.2025.20011

• Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

  Nicolas, A., Sherva, R., Grenier-Boley, B., Kim, Y., Kikuchi, M., Timsina, J., de Rojas, I., Dalmasso, M. C., Zhou, X., Le Guen, Y., Arboleda-Bustos, C. E., Camargos Bicalho, M. A., Guerchet, M., van der Lee, S., Goss, M., Castillo, A., Bellenguez, C., Küçükali, F., Satizabal, C. L., Fongang, B., Yang, Q., Peters, O. & et al.

  Nature Genetics, 57, 1598-1610 doi:10.1038/s41588-025-02227-w

• Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice

  Acuña-Catalán, D., Shah, S., Wehrfritz, C., Nomura, M., Acevedo, A., Olmos, C., Quiroz, G., Huerta, H., Bons, J., Ampuero, E., Wyneken, U., Sanhueza, M., Arancibia, F., Contreras, D., Cárdenas, J. C., Morales, B., Schilling, B., Newman, J. C. & González-Billault, C.

  Cell Reports Medicine, 5, 101593 doi:10.1016/j.xcrm.2024.101593

• A Role for Second Messengers in Axodendritic Neuronal Polarity

  Urrutia, P. J. & González-Billault, C.

  The Journal of Neuroscience, 43, 2037-2052 doi:10.1523/jneurosci.1065-19.2023

• Are cytoskeleton changes observed in astrocytes functionally linked to aging?

  Villablanca, C., Vidal, R. & Gonzalez-Billault, C.

  Brain Research Bulletin, 196, 59-67 doi:10.1016/j.brainresbull.2023.03.007

• Metabolic switch in the aging astrocyte supported via integrative approach comprising network and transcriptome analyses

  Acevedo, A., Torres, F., Kiwi, M., Baeza-Lehnert, F., Barros, L. F., Lee-Liu, D. & González-Billault, C.

  Aging, 15, 9896-9912 doi:10.18632/aging.204663

• The first genome‐wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease

  Dalmasso, M. C., de Rojas, I., Olivar, N., Muchnik, C., Angel, B., Gloger, S., Sanchez Abalos, M. S., Chacón, M. V., Aránguiz, R., Orellana, P., Cuesta, C., Galeano, P., Campanelli, L., Novack, G. V., Martinez, L. E., Medel, N., Lisso, J., Sevillano, Z., Irureta, N., Castaño, E. M., Montrreal, L., Thoenes, M. & et al.

  Alzheimer's & Dementia, 20, 1298-1308 doi:10.1002/alz.13522

• The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis

  Duran-Aniotz, C., Poblete, N., Rivera-Krstulovic, C., Ardiles, Á. O., Díaz-Hung, M. L., Tamburini, G., Sabusap, C. M. P., Gerakis, Y., Cabral-Miranda, F., Diaz, J., Fuentealba, M., Arriagada, D., Muñoz, E., Espinoza, S., Martinez, G., Quiroz, G., Sardi, P., Medinas, D. B., Contreras, D., Piña, R., Lourenco, M. V., Ribeiro, F. C. & et al.

  Molecular Therapy, 31, 2240-2256 doi:10.1016/j.ymthe.2023.03.028

• Akkermansia muciniphila induces mitochondrial calcium overload and α -synuclein aggregation in an enteroendocrine cell line

  Amorim Neto, D. P., Bosque, B. P., Pereira de Godoy, J. V., Rodrigues, P. V., Meneses, D. D., Tostes, K., Costa Tonoli, C. C., Faustino de Carvalho, H., González-Billault, C. & de Castro Fonseca, M.

  iScience, 25, 103908 doi:10.1016/j.isci.2022.103908

• Multiple events case–control study in a prospective cohort to identify systemic, cellular, and molecular biomarkers of obesity-induced accelerated aging in 30-years-olds: the ObAGE study protocol

  Correa-Burrows, P., Burrows, R., Albala, C., Court, F., Salech, F., Sanhueza, G. & Gonzalez-Billault, C.

  BMC Geriatrics, 22 doi:10.1186/s12877-022-03032-4

• Directly Reprogrammed Human Neurons to Understand Age‐Related Energy Metabolism Impairment and Mitochondrial Dysfunction in Healthy Aging and Neurodegeneration

  Gudenschwager, C., Chavez, I., Cardenas, C. & Gonzalez-Billault, C.

  Oxidative Medicine and Cellular Longevity, 2021 doi:10.1155/2021/5586052

• Life-long arsenic exposure damages the microstructure of the rat hippocampus

  Niño, S. A., Chi-Ahumada, E., Carrizales, L., Estrada-Sánchez, A. M., Gonzalez-Billault, C., Zarazúa, S., Concha, L. & Jiménez-Capdeville, M. E.

  Brain Research, 1775, 147742 doi:10.1016/j.brainres.2021.147742

• Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis

  Bilches Medinas, D., Malik, S., Yıldız‐Bölükbaşı, E., Borgonovo, J., Saaranen, M. J., Urra, H., Pulgar, E., Afzal, M., Contreras, D., Wright, M. T., Bodaleo, F., Quiroz, G., Rozas, P., Mumtaz, S., Díaz, R., Rozas, C., Cabral‐Miranda, F., Piña, R., Valenzuela, V., Uyan, O., Reardon, C., Woehlbier, U. & et al.

  The EMBO Journal, 41 doi:10.15252/embj.2020105531

• Neuron‐intrinsic origin of hyperexcitability during early pathogenesis of Alzheimer’s disease

  Lee‐Liu, D. & Gonzalez‐Billault, C.

  Journal of Neurochemistry, 158, 586-588 doi:10.1111/jnc.15248

• Tuba Activates Cdc42 during Neuronal Polarization Downstream of the Small GTPase Rab8a

  Urrutia, P. J., Bodaleo, F., Bórquez, D. A., Homma, Y., Rozes-Salvador, V., Villablanca, C., Conde, C., Fukuda, M. & González-Billault, C.

  The Journal of Neuroscience, 41, 1636-1649 doi:10.1523/jneurosci.0633-20.2020

• Wnt5a modulates dendritic spine dynamics through the regulation of Cofilin via small Rho GTPase activity in hippocampal neurons

  Vallejo, D., Lindsay, C. B., González‐Billault, C. & Inestrosa, N. C.

  Journal of Neurochemistry, 158, 673-693 doi:10.1111/jnc.15448

• Alzheimer’s Disease or Behavioral Variant Frontotemporal Dementia? Review of Key Points Toward an Accurate Clinical and Neuropsychological Diagnosis

  Musa, G., Slachevsky, A., Muñoz-Neira, C., Méndez-Orellana, C., Villagra, R., González-Billault, C., Ibáñez, A., Hornberger, M. & Lillo, P.

  Journal of Alzheimer’s Disease, 73, 833-848 doi:10.3233/jad-190924

• Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca2+ Transfer to Mitochondria

  Lovy, A., Ahumada-Castro, U., Bustos, G., Farias, P., Gonzalez-Billault, C., Molgó, J. & Cardenas, C.

  Frontiers in Cell and Developmental Biology, 8 doi:10.3389/fcell.2020.00378

• Dementia in Latin America: Paving the way toward a regional action plan

  Parra, M. A., Baez, S., Sedeño, L., Gonzalez Campo, C., Santamaría‐García, H., Aprahamian, I., Bertolucci, P. H., Bustin, J., Camargos Bicalho, M. A., Cano‐Gutierrez, C., Caramelli, P., Chaves, M. L. F., Cogram, P., Beber, B. C., Court, F. A., de Souza, L. C., Custodio, N., Damian, A., de la Cruz, M., Diehl Rodriguez, R., Brucki, S. M. D., Fajersztajn, L. & et al.

  Alzheimer's & Dementia, 17, 295-313 doi:10.1002/alz.12202

• Fine-Tuning the TGFβ Signaling Pathway by SARA During Neuronal Development

  Rozés-Salvador, V., Wilson, C., Olmos, C., Gonzalez-Billault, C. & Conde, C.

  Frontiers in Cell and Developmental Biology, 8 doi:10.3389/fcell.2020.550267

• GERO Cohort Protocol, Chile, 2017–2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly

  Slachevsky, A., Zitko, P., Martínez-Pernía, D., Forno, G., Court, F. A., Lillo, P., Villagra, R., Duran-Aniotz, C., Parrao, T., Assar, R., Orellana, P., Toledo, C., Rivera, R., Ibañez, A., Parra, M. A., González-Billault, C., Amieva, H. & Thumala, D.

  BMC Geriatrics, 20 doi:10.1186/s12877-020-01866-4

• Geroscience in the Age of COVID-19

  Barzilai, N., Appleby, J. C., Austad, S. N., Cuervo, A. M., Kaeberlein, M., Gonzalez-Billault, C., Lederman, S., Stambler, I. & Sierra, F.

  Aging and disease, 11, 725 doi:10.14336/ad.2020.0629

• Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates

  García-Huerta, P., Troncoso-Escudero, P., Wu, D., Thiruvalluvan, A., Cisternas-Olmedo, M., Henríquez, D. R., Plate, L., Chana-Cuevas, P., Saquel, C., Thielen, P., Longo, K. A., Geddes, B. J., Lederkremer, G. Z., Sharma, N., Shenkman, M., Naphade, S., Sardi, S. P., Spichiger, C., Richter, H. G., Court, F. A., Tshilenge, K. T., Ellerby, L. M. & et al.

  Acta Neuropathologica, 140, 737-764 doi:10.1007/s00401-020-02183-1

• Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease

  Muñoz, P., Ardiles, Á. O., Pérez-Espinosa, B., Núñez-Espinosa, C., Paula-Lima, A., González-Billault, C. & Espinosa-Parrilla, Y.

  Mechanisms of Ageing and Development, 189, 111250 doi:10.1016/j.mad.2020.111250

• The impact of SARS‐CoV‐2 in dementia across Latin America: A call for an urgent regional plan and coordinated response

  Ibanez, A., Santamaria‐Garcia, H., Guerrero Barragan, A., Kornhuber, A., Ton, A. M. M., Slachevsky, A., Teixeira, A. L., Mar Meza, B. M., Serrano, C. M., Cano, C., Arias Gonzalez, C., Gonzalez‐Billault, C., Butler, C., Bustin, J., Duran‐Aniotz, C., Acosta, D., Matallana, D. L., Acosta‐Alvear, D., Trépel, D., Resende, E. D. P. F., de Oliveira, F. F., Ibanez, F. & et al.

  Alzheimer's & Dementia: Translational Research & Clinical Interventions, 6 doi:10.1002/trc2.12092

• The power of knowledge about dementia in Latin America across health professionals working on aging

  Ibanez, A., Flichtentrei, D., Hesse, E., Dottori, M., Tomio, A., Slachevsky, A., Serrano, C. M., Gonzalez‐Billaut, C., Custodio, N., Miranda, C., Bustin, J., Cetckovitch, M., Torrente, F., Olavarria, L., Leon, T., Beber, B. C., Bruki, S., Suemoto, C. K., Nitrini, R., Miller, B. L. & Yokoyama, J. S.

  Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 12 doi:10.1002/dad2.12117

• The Recycling Endosome in Nerve Cell Development: One Rab to Rule Them All?

  Rozés-Salvador, V., González-Billault, C. & Conde, C.

  Frontiers in Cell and Developmental Biology, 8 doi:10.3389/fcell.2020.603794

• Tubulin polyglutamylation is a general traffic-control mechanism in hippocampal neurons

  Bodakuntla, S., Schnitzler, A., Villablanca, C., Gonzalez-Billault, C., Bieche, I., Janke, C. & Magiera, M. M.

  Journal of Cell Science, 133 doi:10.1242/jcs.241802

• Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders

  Espinosa-Parrilla, Y., Gonzalez-Billault, C., Fuentes, E., Palomo, I. & Alarcón, M.

  Frontiers in Aging Neuroscience, 11 doi:10.3389/fnagi.2019.00151

• Microtubule-Associated Proteins: Structuring the Cytoskeleton

  Bodakuntla, S., Jijumon, A., Villablanca, C., Gonzalez-Billault, C. & Janke, C.

  Trends in Cell Biology, 29, 804-819 doi:10.1016/j.tcb.2019.07.004

• Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

  Carreras-Sureda, A., Jaña, F., Urra, H., Durand, S., Mortenson, D. E., Sagredo, A., Bustos, G., Hazari, Y., Ramos-Fernández, E., Sassano, M. L., Pihán, P., van Vliet, A. R., González-Quiroz, M., Torres, A. K., Tapia-Rojas, C., Kerkhofs, M., Vicente, R., Kaufman, R. J., Inestrosa, N. C., Gonzalez-Billault, C., Wiseman, R. L., Agostinis, P. & et al.

  Nature Cell Biology, 21, 755-767 doi:10.1038/s41556-019-0329-y

• Structural and Functional Abnormalities in the Olfactory System of Fragile X Syndrome Models

  Bodaleo, F., Tapia-Monsalves, C., Cea-Del Rio, C., Gonzalez-Billault, C. & Nunez-Parra, A.

  Frontiers in Molecular Neuroscience, 12 doi:10.3389/fnmol.2019.00135

• Crosstalk between Rac1-mediated actin regulation and ROS production

  Acevedo, A. & González-Billault, C.

  Free Radical Biology and Medicine, 116, 101-113 doi:10.1016/j.freeradbiomed.2018.01.008

• Editorial: From Ecology to Brain Development: Bridging Separate Evolutionary Paradigms

  Aboitiz, F., Concha, M. L., González-Billault, C. & Mpodozis, J.

  Frontiers in Neuroscience, 12 doi:10.3389/fnins.2018.00447

• IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A

  Urra, H., Henriquez, D. R., Cánovas, J., Villarroel-Campos, D., Carreras-Sureda, A., Pulgar, E., Molina, E., Hazari, Y. M., Limia, C. M., Alvarez-Rojas, S., Figueroa, R., Vidal, R. L., Rodriguez, D. A., Rivera, C. A., Court, F. A., Couve, A., Qi, L., Chevet, E., Akai, R., Iwawaki, T., Concha, M. L., Glavic, Á. & et al.

  Nature Cell Biology, 20, 942-953 doi:10.1038/s41556-018-0141-0

• Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging

  Müller, M., Ahumada-Castro, U., Sanhueza, M., Gonzalez-Billault, C., Court, F. A. & Cárdenas, C.

  Frontiers in Neuroscience, 12 doi:10.3389/fnins.2018.00470

• TNF-α Increases Production of Reactive Oxygen Species through Cdk5 Activation in Nociceptive Neurons

  Sandoval, R., Lazcano, P., Ferrari, F., Pinto-Pardo, N., González-Billault, C. & Utreras, E.

  Frontiers in Physiology, 9 doi:10.3389/fphys.2018.00065

• Aging and Health Policies in Chile: New Agendas for Research

  Thumala, D., Kennedy, B. K., Calvo, E., Gonzalez-Billault, C., Zitko, P., Lillo, P., Villagra, R., Ibáñez, A., Assar, R., Andrade, M. & Slachevsky, A.

  Health Systems & Reform, 3, 253-260 doi:10.1080/23288604.2017.1353844

• Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth

  Furusawa, K., Asada, A., Urrutia, P., Gonzalez-Billault, C., Fukuda, M. & Hisanaga, S. I.

  The Journal of Neuroscience, 37, 790-806 doi:10.1523/jneurosci.2197-16.2016

• Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372

  Coddou, C., Sandoval, R., Castro, P., Lazcano, P., Hevia, M. J., Rokic, M., Hall, B., Terse, A., Gonzalez-Billault, C., Kulkarni, A. B., Stojilkovic, S. S. & Utreras, E.

  Pain, 158, 2155-2168 doi:10.1097/j.pain.0000000000001021

• From birth to death: A role for reactive oxygen species in neuronal development

  Wilson, C., Muñoz-Palma, E. & González-Billault, C.

  Seminars in Cell & Developmental Biology, 80, 43-49 doi:10.1016/j.semcdb.2017.09.012

• Hepcidin attenuates amyloid beta‐induced inflammatory and pro‐oxidant responses in astrocytes and microglia

  Urrutia, P. J., Hirsch, E. C., González‐Billault, C. & Núñez, M. T.

  Journal of Neurochemistry, 142, 140-152 doi:10.1111/jnc.14005

• Identity of the <scp>P</scp>urkinje cell cytoplasmic antibody type 2 autoantibody antigen is finally revealed

  Gonzalez‐Billault, C.

  Annals of Neurology, 81, 618-619 doi:10.1002/ana.24884

• Microtubule‐regulating proteins and cAMP‐dependent signaling in neuroblastoma differentiation

  Muñoz‐Llancao, P., de Gregorio, C., Las Heras, M., Meinohl, C., Noorman, K., Boddeke, E., Cheng, X., Lezoualc'h, F., Schmidt, M. & Gonzalez‐Billault, C.

  Cytoskeleton, 74, 143-158 doi:10.1002/cm.21355

• A Feed-Forward Mechanism Involving the NOX Complex and RyR-Mediated Ca²⁺Release During Axonal Specification

  Wilson, C., Muñoz-Palma, E., Henríquez, D. R., Palmisano, I., Núñez, M. T., Di Giovanni, S. & González-Billault, C.

  The Journal of Neuroscience, 36, 11107-11119 doi:10.1523/jneurosci.1455-16.2016

• Actin filaments—A target for redox regulation

  Wilson, C., Terman, J. R., González‐Billault, C. & Ahmed, G.

  Cytoskeleton, 73, 577-595 doi:10.1002/cm.21315

• CDK5 downregulation enhances synaptic plasticity

  Posada-Duque, R. A., Ramirez, O., Härtel, S., Inestrosa, N. C., Bodaleo, F., González-Billault, C., Kirkwood, A. & Cardona-Gómez, G. P.

  Cellular and Molecular Life Sciences, 74, 153-172 doi:10.1007/s00018-016-2333-8

• Cellular and molecular mechanisms regulating neuronal growth by brain‐derived neurotrophic factor

  Gonzalez, A., Moya‐Alvarado, G., Gonzalez‐Billaut, C. & Bronfman, F. C.

  Cytoskeleton, 73, 612-628 doi:10.1002/cm.21312

• Dissecting the role of redox signaling in neuronal development

  Bórquez, D. A., Urrutia, P. J., Wilson, C., van Zundert, B., Núñez, M. T. & González‐Billault, C.

  Journal of Neurochemistry, 137, 506-517 doi:10.1111/jnc.13581

• Ligand-mediated Galectin-1 endocytosis prevents intraneural H2O2 production promoting F-actin dynamics reactivation and axonal re-growth

  Quintá, H. R., Wilson, C., Blidner, A. G., González-Billault, C., Pasquini, L. A., Rabinovich, G. A. & Pasquini, J. M.

  Experimental Neurology, 283, 165-178 doi:10.1016/j.expneurol.2016.06.009

• Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology

  Bodaleo, F. J., Montenegro-Venegas, C., Henríquez, D. R., Court, F. A. & Gonzalez-Billault, C.

  Scientific Reports, 6 doi:10.1038/srep30069

• p120‐catenin is necessary for neuroprotection induced by <scp>CDK</scp>5 silencing in models of Alzheimer's disease

  Uribe‐Arias, A., Posada‐Duque, R. A., González‐Billault, C., Villegas, A., Lopera, F. & Cardona‐Gómez, G. P.

  Journal of Neurochemistry, 138, 624-639 doi:10.1111/jnc.13697

• Rab GTPase signaling in neurite outgrowth and axon specification

  Villarroel‐Campos, D., Bronfman, F. C. & Gonzalez‐Billault, C.

  Cytoskeleton, 73, 498-507 doi:10.1002/cm.21303

• Rab35 Functions in Axon Elongation Are Regulated by P53-Related Protein Kinase in a Mechanism That Involves Rab35 Protein Degradation and the Microtubule-Associated Protein 1B

  Villarroel-Campos, D., Henriquez, D. R., Bodaleo, F. J., Oguchi, M. E., Bronfman, F. C., Fukuda, M. & Gonzalez-Billault, C.

  Journal of Neuroscience, 36, 7298-7313 doi:10.1523/jneurosci.4064-15.2016

• Targeted overexpression of tumor necrosis factor-α increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons

  Rozas, P., Lazcano, P., Piña, R., Cho, A., Terse, A., Pertusa, M., Madrid, R., Gonzalez-Billault, C., Kulkarni, A. B. & Utreras, E.

  Pain, 157, 1346-1362 doi:10.1097/j.pain.0000000000000527

• The Presynaptic Microtubule Cytoskeleton in Physiological and Pathological Conditions: Lessons from Drosophila Fragile X Syndrome and Hereditary Spastic Paraplegias

  Bodaleo, F. J. & Gonzalez-Billault, C.

  Frontiers in Molecular Neuroscience, 9 doi:10.3389/fnmol.2016.00060

• Contribution of NADPH-oxidase to the establishment of hippocampal neuronal polarity in culture

  Wilson, C., Núñez, M. T. & González-Billault, C.

  Journal of Cell Science doi:10.1242/jcs.168567

• Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B

  Munoz-Llancao, P., Henriquez, D. R., Wilson, C., Bodaleo, F., Boddeke, E. W., Lezoualc'h, F., Schmidt, M. & Gonzalez-Billault, C.

  Journal of Neuroscience, 35, 11315-11329 doi:10.1523/jneurosci.3645-14.2015

• Iron Chelators and Antioxidants Regenerate Neuritic Tree and Nigrostriatal Fibers of MPP+/MPTP-Lesioned Dopaminergic Neurons

  Aguirre, P., Mena, N. P., Carrasco, C. M., Muñoz, Y., Pérez-Henríquez, P., Morales, R. A., Cassels, B. K., Méndez-Gálvez, C., García-Beltrán, O., González-Billault, C. & Núñez, M. T.

  PLOS ONE, 10, e0144848 doi:10.1371/journal.pone.0144848

• p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing

  Posada‐Duque, R. A., López‐Tobón, A., Piedrahita, D., González‐Billault, C. & Cardona‐Gomez, G. P.

  Journal of Neurochemistry, 134, 354-370 doi:10.1111/jnc.13127

• Prenatal Stress Down-Regulates Reelin Expression by Methylation of Its Promoter and Induces Adult Behavioral Impairments in Rats

  Palacios-García, I., Lara-Vásquez, A., Montiel, J. F., Díaz-Véliz, G. F., Sepúlveda, H., Utreras, E., Montecino, M., González-Billault, C. & Aboitiz, F.

  PLOS ONE, 10, e0117680 doi:10.1371/journal.pone.0117680

• Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking

  Wilson, C. & González-Billault, C.

  Frontiers in Cellular Neuroscience, 9 doi:10.3389/fncel.2015.00381

• Regulation of Neuronal Cav3.1 Channels by Cyclin-Dependent Kinase 5 (Cdk5)

  Calderón-Rivera, A., Sandoval, A., González-Ramírez, R., González-Billault, C. & Felix, R.

  PLOS ONE, 10, e0119134 doi:10.1371/journal.pone.0119134

• CaV2.2 channel cell surface expression is regulated by the light chain 1 (LC1) of the microtubule-associated protein B (MAP1B) via UBE2L3-mediated ubiquitination and degradation

  Gandini, M. A., Henríquez, D. R., Grimaldo, L., Sandoval, A., Altier, C., Zamponi, G. W., Felix, R. & González-Billault, C.

  Pflügers Archiv - European Journal of Physiology, 466, 2113-2126 doi:10.1007/s00424-014-1476-4

• Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization

  Kahn, O. I., Sharma, V., González-Billault, C. & Baas, P. W.

  Molecular Biology of the Cell, 26, 66-77 doi:10.1091/mbc.e14-08-1313

• Emerging concepts on neuronal cytoskeleton

  Gonzalez‐Billault, C. & Letourneau, P.

  Journal of Neurochemistry, 129, 205-205 doi:10.1111/jnc.12674

• Rab‐mediated trafficking role in neurite formation

  Villarroel‐Campos, D., Gastaldi, L., Conde, C., Caceres, A. & Gonzalez‐Billault, C.

  Journal of Neurochemistry, 129, 240-248 doi:10.1111/jnc.12676

• <scp>A</scp>‐kinase anchoring proteins: <scp>cAMP</scp> compartmentalization in neurodegenerative and obstructive pulmonary diseases

  Poppinga, W. J., Muñoz‐Llancao, P., González‐Billault, C. & Schmidt, M.

  British Journal of Pharmacology, 171, 5603-5623 doi:10.1111/bph.12882

• Searching for Novel Cdk5 Substrates in Brain by Comparative Phosphoproteomics of Wild Type and Cdk5−/− Mice

  Contreras-Vallejos, E., Utreras, E., Bórquez, D. A., Prochazkova, M., Terse, A., Jaffe, H., Toledo, A., Arruti, C., Pant, H. C., Kulkarni, A. B. & González-Billault, C.

  PLoS ONE, 9, e90363 doi:10.1371/journal.pone.0090363

• The MAP1B case: An old MAP that is new again

  Villarroel‐Campos, D. & Gonzalez‐Billault, C.

  Developmental Neurobiology, 74, 953-971 doi:10.1002/dneu.22178

• Actin filaments and microtubules in dendritic spines

  Shirao, T. & González‐Billault, C.

  Journal of Neurochemistry, 126, 155-164 doi:10.1111/jnc.12313

• Bioinformatic survey for new physiological substrates of Cyclin-dependent kinase 5

  Bórquez, D. A., Olmos, C., Álvarez, S., Di Genova, A., Maass, A. & González-Billault, C.

  Genomics, 101, 221-228 doi:10.1016/j.ygeno.2013.01.003

• Ca2+-Activated Cl− Channels of the ClCa Family Express in the Cilia of a Subset of Rat Olfactory Sensory Neurons

  Gonzalez-Silva, C., Vera, J., Bono, M. R., González-Billault, C., Baxter, B., Hansen, A., Lopez, R., Gibson, E. A., Restrepo, D. & Bacigalupo, J.

  PLoS ONE, 8, e69295 doi:10.1371/journal.pone.0069295

• Cdk5 regulates Rap1 activity

  Utreras, E., Henriquez, D., Contreras-Vallejos, E., Olmos, C., Di Genova, A., Maass, A., Kulkarni, A. B. & Gonzalez-Billault, C.

  Neurochemistry International, 62, 848-853 doi:10.1016/j.neuint.2013.02.011

• Frizzled-5 Receptor Is Involved in Neuronal Polarity and Morphogenesis of Hippocampal Neurons

  Slater, P. G., Ramirez, V. T., Gonzalez-Billault, C., Varela-Nallar, L. & Inestrosa, N. C.

  PLoS ONE, 8, e78892 doi:10.1371/journal.pone.0078892

• Inflammation alters the expression of <scp>DMT</scp> 1, <scp>FPN</scp> 1 and hepcidin, and it causes iron accumulation in central nervous system cells

  Urrutia, P., Aguirre, P., Esparza, A., Tapia, V., Mena, N. P., Arredondo, M., González‐Billault, C. & Núñez, M. T.

  Journal of Neurochemistry, 126, 541-549 doi:10.1111/jnc.12244

• MAP1B‐dependent Rac activation is required for AMPA receptor endocytosis during long‐term depression

  Benoist, M., Palenzuela, R., Rozas, C., Rojas, P., Tortosa, E., Morales, B., González‐Billault, C., Ávila, J. & Esteban, J. A.

  The EMBO Journal, 32, 2287-2299 doi:10.1038/emboj.2013.166

• A gathering of neuronal cytoskeletal scientists in South America

  Baas, P. W. & Gonzalez‐Billault, C.

  Cytoskeleton, 69, 407-415 doi:10.1002/cm.21038

• BH3‐only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α

  Rodriguez, D. A., Zamorano, S., Lisbona, F., Rojas‐Rivera, D., Urra, H., Cubillos‐Ruiz, J. R., Armisen, R., Henriquez, D. R., H Cheng, E., Letek, M., Vaisar, T., Irrazabal, T., Gonzalez‐Billault, C., Letai, A., Pimentel‐Muiños, F. X., Kroemer, G. & Hetz, C.

  The EMBO Journal, 31, 2322-2335 doi:10.1038/emboj.2012.84

• Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease

  Cabeza, C., Figueroa, A., Lazo, O. M., Galleguillos, C., Pissani, C., Klein, A., Gonzalez-Billault, C., Inestrosa, N. C., Alvarez, A. R., Zanlungo, S. & Bronfman, F. C.

  Molecular Neurodegeneration, 7 doi:10.1186/1750-1326-7-11

• Fibrillar Amyloid-β1-42 Modifies Actin Organization Affecting the Cofilin Phosphorylation State: A Role for Rac1/cdc42 Effector Proteins and the Slingshot Phosphatase

  Mendoza-Naranjo, A., Contreras-Vallejos, E., Henriquez, D. R., Otth, C., Bamburg, J. R., Maccioni, R. B. & Gonzalez-Billault, C.

  Journal of Alzheimer's Disease, 29, 63-77 doi:10.3233/jad-2012-101575

• Frizzled receptors in neurons: From growth cones to the synapse

  Varela‐Nallar, L., Ramirez, V. T., Gonzalez‐Billault, C. & Inestrosa, N. C.

  Cytoskeleton, 69, 528-534 doi:10.1002/cm.21022

• The Amyloid Precursor Protein Intracellular Domain-Fe65 Multiprotein Complexes: A Challenge to the Amyloid Hypothesis for Alzheimer's Disease?

  Bórquez, D. A. & González-Billault, C.

  International Journal of Alzheimer's Disease, 2012, 1-10 doi:10.1155/2012/353145

• The Light Chain 1 Subunit of the Microtubule-Associated Protein 1B (MAP1B) Is Responsible for Tiam1 Binding and Rac1 Activation in Neuronal Cells

  Henríquez, D. R., Bodaleo, F. J., Montenegro-Venegas, C. & González-Billault, C.

  PLoS ONE, 7, e53123 doi:10.1371/journal.pone.0053123

• The role of small GTPases in neuronal morphogenesis and polarity

  Gonzalez‐Billault, C., Muñoz‐Llancao, P., Henriquez, D. R., Wojnacki, J., Conde, C. & Caceres, A.

  Cytoskeleton, 69, 464-485 doi:10.1002/cm.21034

• Contributions by researchers of "Ciencia de Frontera" of the Chilean Academy of Sciences

  Biological Research

• Going out of the brain: Non-nervous system physiological and pathological functions of Cdk5

  Contreras-Vallejos, E., Utreras, E. & Gonzalez-Billault, C.

  Cellular Signalling, 24, 44-52 doi:10.1016/j.cellsig.2011.08.022

• Microtubule-associated Protein 1B (MAP1B) Is Required for Dendritic Spine Development and Synaptic Maturation

  Tortosa, E., Montenegro-Venegas, C., Benoist, M., Härtel, S., González-Billault, C., Esteban, J. A. & Avila, J.

  Journal of Biological Chemistry, 286, 40638-40648 doi:10.1074/jbc.m111.271320

• Regulation of cell polarity by controlled proteolytic systems

  Bórquez, D. A. & González-Billault, C.

  Biological Research, 44, 35-41 doi:10.4067/s0716-97602011000100005

• Iron mediates neuritic tree collapse in mesencephalic neurons treated with 1-methyl-4-phenylpyridinium (MPP+)

  Gómez, F. J., Aguirre, P., Gonzalez-Billault, C. & Núñez, M. T.

  Journal of Neural Transmission, 118, 421-431 doi:10.1007/s00702-010-0489-1

• MAP1B Regulates Axonal Development by Modulating Rho-GTPase Rac1 Activity

  Montenegro-Venegas, C., Tortosa, E., Rosso, S., Peretti, D., Bollati, F., Bisbal, M., Jausoro, I., Avila, J., Cáceres, A. & Gonzalez-Billault, C.

  Molecular Biology of the Cell, 21, 3518-3528 doi:10.1091/mbc.e09-08-0709

• Cyclin-dependent kinase 5 activator p35 over-expression and amyloid beta synergism increase apoptosis in cultured neuronal cells

  Utreras, E., Maccioni, R. & González-Billault, C.

  Neuroscience, 161, 978-987 doi:10.1016/j.neuroscience.2009.04.002

• Microtubule-Associated Protein 1B Interaction with Tubulin Tyrosine Ligase Contributes to the Control of Microtubule Tyrosination

  Utreras, E., Jiménez-Mateos, E. M., Contreras-Vallejos, E., Tortosa, E., Pérez, M., Rojas, S., Saragoni, L., Maccioni, R. B., Avila, J. & González-Billault, C.

  Developmental Neuroscience, 30, 200-210 doi:10.1159/000109863

• Aβ1-42 stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases

  Mendoza-Naranjo, A., Gonzalez-Billault, C. & Maccioni, R. B.

  Journal of Cell Science, 120, 279-288 doi:10.1242/jcs.03323

• Role of MAP1B in axonal retrograde transport of mitochondria

  Jiménez-Mateos, E. M., González-Billault, C., Dawson, H. N., Vitek, M. P. & Avila, J.

  Biochemical Journal, 397, 53-59 doi:10.1042/bj20060205

• Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1

  JiméNez-Mateos, E. M., Wandosell, F., Reiner, O., Avila, J. & González-Billault, C.

  Biochemical Journal, 389, 333-341 doi:10.1042/bj20050244

• End binding protein‐1 (EB1) complements microtubule‐associated protein‐1B during axonogenesis

  Jiménez‐Mateos, E. M., Paglini, G., González‐Billault, C., Cáceres, A. & Avila, J.

  Journal of Neuroscience Research, 80, 350-359 doi:10.1002/jnr.20453

• Role of the JAKs/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons

  Orellana, D. I., Quintanilla, R. A., Gonzalez-Billault, C. & Maccioni, R. B.

  Neurotoxicity Research, 8, 295-304 doi:10.1007/bf03033983

• A role of MAP1B in Reelin-dependent Neuronal Migration

  González-Billault, C., Del Río, J. A., Ureña, J. M., Jiménez-Mateos, E. M., Barallobre, M. J., Pascual, M., Pujadas, L., Simó, S., Torre, A. L., Gavin, R., Wandosell, F., Soriano, E. & Ávila, J.

  Cerebral Cortex, 15, 1134-1145 doi:10.1093/cercor/bhh213

• Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway

  Quintanilla, R. A., Orellana, D. I., González-Billault, C. & Maccioni, R. B.

  Experimental Cell Research, 295, 245-257 doi:10.1016/j.yexcr.2004.01.002

• MAP1B Is Required for Netrin 1 Signaling in Neuronal Migration and Axonal Guidance

  Del Rı́o, J. A., González-Billault, C., Ureña, J. M., Jiménez, E. M., Barallobre, M. J., Pascual, M., Pujadas, L., Simó, S., La Torre, A., Wandosell, F., Ávila, J. & Soriano, E.

  Current Biology, 14, 840-850 doi:10.1016/j.cub.2004.04.046

• Microtubule‐associated protein 1B function during normal development, regeneration, and pathological conditions in the nervous system

  Gonzalez‐Billault, C., Jimenez‐Mateos, E. M., Caceres, A., Diaz‐Nido, J., Wandosell, F. & Avila, J.

  Journal of Neurobiology, 58, 48-59 doi:10.1002/neu.10283

• Oxidative stress promotes τ dephosphorylation in neuronal cells: the roles of cdk5 and PP1

  Zambrano, C. A., Egaña, J. T., Núñez, M. T., Maccioni, R. B. & González-Billault, C.

  Free Radical Biology and Medicine, 36, 1393-1402 doi:10.1016/j.freeradbiomed.2004.03.007

• Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures

  Egaña, J. T., Zambrano, C., Nuñez, M. T., Gonzalez-Billault, C. & Maccioni, R. B.

  Biometals, 16, 215-223 doi:10.1023/a:1020727218493

• AβPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576

  Otth, C., Concha, I. I., Arendt, T., Stieler, J., Schliebs, R., González-Billault, C. & Maccioni, R. B.

  Journal of Alzheimer's Disease, 4, 417-430 doi:10.3233/jad-2002-4508

• Microtubule-associated protein 1B is involved in the initial stages of axonogenesis in peripheral nervous system cultured neurons

  Gonzalez-Billault, C., Owen, R., Gordon-Weeks, P. R. & Avila, J.

  Brain Research, 943, 56-67 doi:10.1016/s0006-8993(02)02534-9

• Participation of structural microtubule‐associated proteins (MAPs) in the development of neuronal polarity

  González‐Billault, C., Engelke, M., Jiménez‐Mateos, E., Wandosell, F., Cáceres, A. & Avila, J.

  Journal of Neuroscience Research, 67, 713-719 doi:10.1002/jnr.10161

• Evidence for the Role of MAP1B in Axon Formation

  Gonzalez-Billault, C., Avila, J. & Cáceres, A.

  Molecular Biology of the Cell, 12, 2087-2098 doi:10.1091/mbc.12.7.2087

• Molecular genetic approaches to microtubule-associated protein function.

  Histology and histopathology

• Perinatal Lethality of Microtubule-Associated Protein 1B-Deficient Mice Expressing Alternative Isoforms of the Protein at Low Levels

  González-Billault, C., Demandt, E., Wandosell, F., Torres, M., Bonaldo, P., Stoykova, A., Chowdhury, K., Gruss, P., Avila, J. & Sánchez, M. P.

  Molecular and Cellular Neuroscience, 16, 408-421 doi:10.1006/mcne.2000.0880

• Modification of tau to an Alzheimer's type protein interferes with its interaction with microtubules

  Cellular and Molecular Biology

• Immunological characterization of epitopes on tau of Alzheimer's type and chemically modified tau

  Far¡as, G., Gonz lez-Billault, C. & Maccioni, R. B.

  Molecular and Cellular Biochemistry, 168, 59-66 doi:10.1023/a:1006838626730