Andrea Cristina Paula Lima

Desde ORCID

• Immunotherapies based on macrophage reprogramming in periodontitis and apical periodontitis

  González-Quintanilla, D., Castro-Saavedra, S., Bordagaray, M. J., Lucero-Mora, J., Vernal, R., Paula-Lima, A., Fernández, A. & Hernández, M.

  Clinical Oral Investigations, 30 doi:10.1007/s00784-026-06918-4

• Metformin Enhances Antioxidant Defenses and Limits Lipid Peroxidation Through the Modulation of Nrf2/KEAP1 Pathway in Hippocampal Neurons Exposed to Amyloid-β Oligomers

  Arriagada, J., Lantadilla, M., Lobos, P., Paz, A. A., Herrera, E. A., Muñoz, P. & Paula-Lima, A.

  Neurotoxicity Research, 44 doi:10.1007/s12640-026-00819-w

• Metformin enhances hippocampal excitatory synaptic transmission and preserves synaptic plasticity under amyloid-β oligomer-induced dysfunction

  Arriagada, J., Ardiles, Á., Mery, E., Garay, C., Conejera, F., Herrera, E. A., Paula-Lima, A. & Muñoz, P.

  Neuropharmacology, 299, 111116 doi:10.1016/j.neuropharm.2026.111116

• Reticulon-1 synthesis controls outgrowth and microtubule dynamics in injured cortical axons

  Luarte, A., Gallardo, J., Corvalán, D., Chakraborty, A., Gouveia Roque, C., Bertin, F., Contreras, C., Ramírez, J. P., Weber, A., Acevedo, W., Zuschratter, W., Herrera-Molina, R., Wyneken, Ú., Paula-Lima, A., Adasme-Rocha, T., Toledo, J., Vergara, R., Figueroa, A., González, C., González-Billault, C., Hengst, U. & Couve, A.

  Life Science Alliance, 9, e202503571 doi:10.26508/lsa.202503571

• Calcium release via IP3R/RyR channels contributes to the nuclear and mitochondrial Ca2+ signals elicited by neuronal stimulation

  Gleitze, S., Ramírez, O. A., Vega-Vásquez, I., Stephan, E., Bengtson, C. P., Paula-Lima, A., Bading, H. & Hidalgo, C.

  Biochemical and Biophysical Research Communications, 754, 151445 doi:10.1016/j.bbrc.2025.151445

• Excitatory-inhibitory synaptic imbalance induced by acute intra-hippocampus injections of amyloid-β oligomers

  Arriagada, J., Mercerón, D., Ardiles, Á., Muñoz, P. & Paula-Lima, A.

  Biochemical and Biophysical Research Communications, 742, 151133 doi:10.1016/j.bbrc.2024.151133

• mHealth to enhance oral cancer awareness in older adults in Chile: a preliminary report

  Morales-Gómez, C. B., Espinoza-Santander, I. L., López-Neira, L., von Marttens, A. H., Borgeat, M. C., Lee, X. M., Cornejo-Ovalle, M. A., Gamonal, J. A., Paula-Lima, A. C., Giacaman, R. A., León, S. & Beltrán, V.

  Exploration of Digital Health Technologies, 3 doi:10.37349/edht.2025.101139

• Local synthesis of Reticulon-1C lessens the outgrowth of injured axons and Spastin activity

  Luarte, A., Gallardo, J., Corvalán, D., Chakraborty, A., Gouveia-Roque, C., Bertin, F., Contreras, C., Ramírez, J. P., Weber, A., Acevedo, W., Zuschratter, W., Herrera-Molina, R., Wyneken, Ú., Paula-Lima, A., Adasme-Rocha, T., Toledo, J., Vergara, R., Figueroa, A., González, C., González-Billault, C., Hengst, U. & Couve, A.

  BioRxiv doi:10.1101/2024.08.11.607514

• Amyloid β-Oligomers Inhibit the Nuclear Ca<sup>2+</sup> Signals and the Neuroprotective Gene Expression Induced by Hippocampal Neuronal Activity

  Lobos, P., Vega-Vásquez, I., Bruna, B., Gleitze, S., Toledo, J., Härtel, S., Hidalgo, C. & Paula-Lima, A.

  doi:10.20944/preprints202310.0984.v1

• Amyloid β-Oligomers Inhibit the Nuclear Ca2+ Signals and the Neuroprotective Gene Expression Induced by Gabazine in Hippocampal Neurons

  Lobos, P., Vega-Vásquez, I., Bruna, B., Gleitze, S., Toledo, J., Härtel, S., Hidalgo, C. & Paula-Lima, A.

  Antioxidants, 12, 1972 doi:10.3390/antiox12111972

• Long-term potentiation and spatial memory training stimulate the hippocampal expression of RyR2 calcium release channels

  Valdés-Undurraga, I., Lobos, P., Sánchez-Robledo, V., Arias-Cavieres, A., SanMartín, C. D., Barrientos, G., More, J., Muñoz, P., Paula-Lima, A. C., Hidalgo, C. & Adasme, T.

  Frontiers in Cellular Neuroscience, 17 doi:10.3389/fncel.2023.1132121

• Periodontal bacteria in the brain—Implication for Alzheimer's disease: A systematic review

  Parra‐Torres, V., Melgar‐Rodríguez, S., Muñoz‐Manríquez, C., Sanhueza, B., Cafferata, E. A., Paula‐Lima, A. C. & Díaz‐Zúñiga, J.

  Oral Diseases, 29, 21-28 doi:10.1111/odi.14054

• Ryanodine Receptor Mediated Calcium Release Contributes to Ferroptosis Induced in Primary Hippocampal Neurons by GPX4 Inhibition

  Gleitze, S., Ramírez, O. A., Vega-Vásquez, I., Yan, J., Lobos, P., Bading, H., Núñez, M. T., Paula-Lima, A. & Hidalgo, C.

  Antioxidants, 12, 705 doi:10.3390/antiox12030705

• RyR-mediated calcium release in hippocampal health and disease

  Hidalgo, C. & Paula-Lima, A.

  Trends in Molecular Medicine, 30, 25-36 doi:10.1016/j.molmed.2023.10.008

• Visual-spatial processing impairment in the occipital-frontal connectivity network at early stages of Alzheimer’s disease

  Plaza-Rosales, I., Brunetti, E., Montefusco-Siegmund, R., Madariaga, S., Hafelin, R., Ponce, D. P., Behrens, M. I., Maldonado, P. E. & Paula-Lima, A.

  Frontiers in Aging Neuroscience, 15 doi:10.3389/fnagi.2023.1097577

• Editorial: Molecular mechanisms of Alzheimer’s disease: From top to bottom

  Mello-Carpes, P. B., Inestrosa, N. C. & Paula-Lima, A. C.

  Frontiers in Aging, 3 doi:10.3389/fragi.2022.1026942

• Hippocampal dendritic spines express the RyR3 but not the RyR2 ryanodine receptor isoform

  Vega-Vásquez, I., Lobos, P., Toledo, J., Adasme, T., Paula-Lima, A. & Hidalgo, C.

  Biochemical and Biophysical Research Communications, 633, 96-103 doi:10.1016/j.bbrc.2022.10.024

• Gingival Crevicular Fluid as Biomarker’s Source for Alzheimer’s Disease

  Sansores-España, L. D., Morales, F., Arriola-Pacheco, F., Astorga, J., Paula-Lima, A., Carrillo-Ávila, A., Melgar-Rodríguez, S., Martínez-Aguilar, V. & Díaz-Zúñiga, J.

  Odovtos - International Journal of Dental Sciences, 24, 156-176 doi:10.15517/ijds.2022.49232

• Oral-Gut-Brain Axis in Experimental Models of Periodontitis: Associating Gut Dysbiosis With Neurodegenerative Diseases

  Sansores-España, L. D., Melgar-Rodríguez, S., Olivares-Sagredo, K., Cafferata, E. A., Martínez-Aguilar, V. M., Vernal, R., Paula-Lima, A. C. & Díaz-Zúñiga, J.

  Frontiers in Aging, 2 doi:10.3389/fragi.2021.781582

• RyR-mediated Ca ²⁺ release elicited by neuronal activity induces nuclear Ca ²⁺ signals, CREB phosphorylation, and Npas4/RyR2 expression

  Lobos, P., Córdova, A., Vega-Vásquez, I., Ramírez, O. A., Adasme, T., Toledo, J., Cerda, M., Härtel, S., Paula-Lima, A. & Hidalgo, C.

  Proceedings of the National Academy of Sciences, 118 doi:10.1073/pnas.2102265118

• The calcium–iron connection in ferroptosis-mediated neuronal death

  Gleitze, S., Paula-Lima, A., Núñez, M. T. & Hidalgo, C.

  Free Radical Biology and Medicine, 175, 28-41 doi:10.1016/j.freeradbiomed.2021.08.231

• Alzheimer’s Disease-Like Pathology Triggered by Porphyromonas gingivalis in Wild Type Rats Is Serotype Dependent

  Díaz-Zúñiga, J., More, J., Melgar-Rodríguez, S., Jiménez-Unión, M., Villalobos-Orchard, F., Muñoz-Manríquez, C., Monasterio, G., Valdés, J. L., Vernal, R. & Paula-Lima, A.

  Frontiers in Immunology, 11 doi:10.3389/fimmu.2020.588036

• Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation

  García, F., Lobos, P., Ponce, A., Cataldo, K., Meza, D., Farías, P., Estay, C., Oyarzun-Ampuero, F., Herrera-Molina, R., Paula-Lima, A., Ardiles, Á. O., Hidalgo, C., Adasme, T. & Muñoz, P.

  Marine Drugs, 18, 335 doi:10.3390/md18060335

• Differential navigational strategies during spatial learning in a new modified version of the Oasis maze

  Concha-Miranda, M., More, J., Grinspun, N., Sanchez, C., Paula-Lima, A. & Valdés, J. L.

  Behavioural Brain Research, 385, 112555 doi:10.1016/j.bbr.2020.112555

• Latin America: Reduced S&T Investment Puts Sustainable Development at Risk

  Bolaños-Villegas, P., Cabrerizo, F., Brown, F., Zancan, P., Barrera, J. F., González-Muñoz, P. A., Grecco, H., Kalergis, A., Paula-Lima, A., Vargas-Balda, R., Gittens, R., López Vergès, S. & Wilson, C.

  ScienceOpen Preprints doi:10.14293/s2199-1006.1.sor-.ppbpkuj.v1

• Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer’s Disease

  Salech, F., Ponce, D. P., Paula-Lima, A. C., SanMartin, C. D. & Behrens, M. I.

  Frontiers in Aging Neuroscience, 12 doi:10.3389/fnagi.2020.00255

• Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease

  Muñoz, P., Ardiles, Á. O., Pérez-Espinosa, B., Núñez-Espinosa, C., Paula-Lima, A., González-Billault, C. & Espinosa-Parrilla, Y.

  Mechanisms of Ageing and Development, 189, 111250 doi:10.1016/j.mad.2020.111250

• Serotype b of <i>Aggregatibacter actinomycetemcomitans</i> triggers pro-inflammatory responses and amyloid beta secretion in hippocampal cells: a novel link between periodontitis and Alzheimer´s disease?

  Díaz-Zúñiga, J., Muñoz, Y., Melgar-Rodríguez, S., More, J., Bruna, B., Lobos, P., Monasterio, G., Vernal, R. & Paula-Lima, A.

  Journal of Oral Microbiology, 11, 1586423 doi:10.1080/20002297.2019.1586423

• Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory

  More, J. Y., Bruna, B. A., Lobos, P. E., Galaz, J. L., Figueroa, P. L., Namias, S., Sánchez, G. L., Barrientos, G. C., Valdés, J. L., Paula-Lima, A. C., Hidalgo, C. & Adasme, T.

  Antioxidants &amp; Redox Signaling, 29, 1125-1146 doi:10.1089/ars.2017.7277

• N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer’s Disease Rat Model

  More, J., Galusso, N., Veloso, P., Montecinos, L., Finkelstein, J. P., Sanchez, G., Bull, R., Valdés, J. L., Hidalgo, C. & Paula-Lima, A.

  Frontiers in Aging Neuroscience, 10 doi:10.3389/fnagi.2018.00399

• Reactive oxygen species released from astrocytes treated with amyloid beta oligomers elicit neuronal calcium signals that decrease phospho-Ser727-STAT3 nuclear content

  Muñoz, Y., Paula-Lima, A. C. & Núñez, M. T.

  Free Radical Biology and Medicine, 117, 132-144 doi:10.1016/j.freeradbiomed.2018.01.006

• The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K

  Bruna, B., Lobos, P., Herrera-Molina, R., Hidalgo, C., Paula-Lima, A. & Adasme, T.

  Biochemical and Biophysical Research Communications, 505, 201-207 doi:10.1016/j.bbrc.2018.09.080

• RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid β Peptide Oligomers

  SanMartín, C. D., Veloso, P., Adasme, T., Lobos, P., Bruna, B., Galaz, J., García, A., Hartel, S., Hidalgo, C. & Paula-Lima, A. C.

  Frontiers in Molecular Neuroscience, 10 doi:10.3389/fnmol.2017.00115

• Astaxanthin Protects Primary Hippocampal Neurons against Noxious Effects of A <i>β</i> -Oligomers

  Lobos, P., Bruna, B., Cordova, A., Barattini, P., Galáz, J. L., Adasme, T., Hidalgo, C., Muñoz, P. & Paula-Lima, A.

  Neural Plasticity, 2016, 1-13 doi:10.1155/2016/3456783

• Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2+ release without affecting endoplasmic reticulum Ca2+ content in primary hippocampal neurons

  Adasme, T., Paula-Lima, A. & Hidalgo, C.

  Biochemical and Biophysical Research Communications, 458, 57-62 doi:10.1016/j.bbrc.2015.01.065

• <scp>H</scp>₂<scp>O</scp>₂ activates matrix metalloproteinases through the nuclear factor kappa <scp>B</scp> pathway and <scp>C</scp>a²⁺ signals in human periodontal fibroblasts

  Osorio, C., Cavalla, F., Paula‐Lima, A., Díaz‐Araya, G., Vernal, R., Ahumada, P., Gamonal, J. & Hernández, M.

  Journal of Periodontal Research, 50, 798-806 doi:10.1111/jre.12267

• Contribution of Ca ²⁺ Release Channels to Hippocampal Synaptic Plasticity and Spatial Memory: Potential Redox Modulation

  Paula-Lima, A. C., Adasme, T. & Hidalgo, C.

  Antioxidants &amp; Redox Signaling, 21, 892-914 doi:10.1089/ars.2013.5796

• Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca2+ uptake in primary hippocampal neurons

  SanMartín, C. D., Paula-Lima, A. C., García, A., Barattini, P., Hartel, S., Núñez, M. T. & Hidalgo, C.

  Frontiers in Molecular Neuroscience, 7 doi:10.3389/fnmol.2014.00013

• Amyloid β-peptide oligomers, ryanodine receptor-mediated Ca2+ release, and Wnt-5a/Ca2+ signaling: opposing roles in neuronal mitochondrial dynamics?

  Paula-Lima, A. C. & Hidalgo, C.

  Frontiers in Cellular Neuroscience, 7 doi:10.3389/fncel.2013.00120

• Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease

  Paula‐Lima, A. C., Brito‐Moreira, J. & Ferreira, S. T.

  Journal of Neurochemistry, 126, 191-202 doi:10.1111/jnc.12304

• Amyloid-β Oligomers Induce Differential Gene Expression in Adult Human Brain Slices

  Sebollela, A., Freitas-Correa, L., Oliveira, F. F., Paula-Lima, A. C., Saraiva, L. M., Martins, S. M., Mota, L. D., Torres, C., Alves-Leon, S., de Souza, J. M., Carraro, D. M., Brentani, H., De Felice, F. G. & Ferreira, S. T.

  Journal of Biological Chemistry, 287, 7436-7445 doi:10.1074/jbc.m111.298471

• Sub-lethal levels of amyloid β-peptide oligomers decrease non-transferrin-bound iron uptake and do not potentiate iron toxicity in primary hippocampal neurons

  SanMartín, C. D., Paula-Lima, A. C., Hidalgo, C. & Núñez, M. T.

  BioMetals, 25, 805-813 doi:10.1007/s10534-012-9545-7

• The Antioxidant N-Acetylcysteine Prevents the Mitochondrial Fragmentation Induced by Soluble Amyloid-F Peptide Oligomers

  SanMartin, C., Adasme, T., Hidalgo, C. & Paula-Lima, A.

  Neurodegenerative Diseases, 10, 34-37 doi:10.1159/000334901

• A&amp;#946; Oligomers Induce Glutamate Release from Hippocampal Neurons

  Brito-Moreira, J., C. Paula-Lima, A., R. Bomfim, T., F. Oliveira, F., J. Sepulveda, F., G. De Mello, F., G. Aguayo, L., Panizzutti, R. & T. Ferreira, S.

  Current Alzheimer Research, 8, 552-562 doi:10.2174/156720511796391917

• Amyloid β-Peptide Oligomers Stimulate RyR-Mediated Ca ²⁺ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF

  Paula-Lima, A. C., Adasme, T., SanMartín, C., Sebollela, A., Hetz, C., Carrasco, M. A., Ferreira, S. T. & Hidalgo, C.

  Antioxidants &amp; Redox Signaling, 14, 1209-1223 doi:10.1089/ars.2010.3287

• Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation

  Adasme, T., Haeger, P., Paula-Lima, A. C., Espinoza, I., Casas-Alarcón, M. M., Carrasco, M. A. & Hidalgo, C.

  Proceedings of the National Academy of Sciences, 108, 3029-3034 doi:10.1073/pnas.1013580108

• Human apolipoprotein A–I binds amyloid-β and prevents Aβ-induced neurotoxicity

  Paula-Lima, A. C., Tricerri, M. A., Brito-Moreira, J., Bomfim, T. R., Oliveira, F. F., Magdesian, M. H., Grinberg, L. T., Panizzutti, R. & Ferreira, S. T.

  The International Journal of Biochemistry &amp; Cell Biology, 41, 1361-1370 doi:10.1016/j.biocel.2008.12.003

• Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line

  Biological Researchenlace

• Activation of GABAA receptors by taurine and muscimol blocks the neurotoxicity of β-amyloid in rat hippocampal and cortical neurons

  Paula-Lima, A. C., De Felice, F. G., Brito-Moreira, J. & Ferreira, S. T.

  Neuropharmacology, 49, 1140-1148 doi:10.1016/j.neuropharm.2005.06.015

• Taurine prevents the neurotoxicity of β‐amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders

  Louzada, P. R., Lima, A. C. P., Mendonca‐Silva, D. L., Noël, F., De Mello, F. G. & Ferreira, S. T.

  The FASEB Journal, 18, 511-518 doi:10.1096/fj.03-0739com

• Neuroprotection against Aβ and glutamate toxicity by melatonin: Are GABA receptors involved?

  Lima, A. C. P., Louzada, P. R., De Mello, F. G. & Ferreira, S. T.

  Neurotoxicity Research, 5, 323-327 doi:10.1007/bf03033152

• Dual role of glutamatergic neurotransmission on amyloid β1–42 aggregation and neurotoxicity in embryonic avian retina

  Louzada Jr., P. R., Paula Lima, A. C., de Mello, F. G. & Ferreira, S. T.

  Neuroscience Letters, 301, 59-63 doi:10.1016/s0304-3940(01)01585-3