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Académico(a):

Paola Morales Retamales

pmorales@med.uchile.cl

Formación:

  • Licenciada en Ciencias ,Universidad de Chile 1995.
  • Magister ,Universidad de Chile 1995.
  • Doctora en Ciencias Biomédicas ,Universidad de Chile 2005.

Categoría académica:

  • Profesora Asociada Instituto de Ciencias Biomédicas ICBM ,Facultad de Medicina Universidad de Chile

Linea de Investigación 

  • Mesenchymal stem cells-secretome: Protection in neonatal hypoxia-reoxygenation. Mechanisms and translational studies.
  • Asphyxia at birth primes CNS development and increase the vulnerability to subsequent postnatal insults
  • Nanoinmunoterapia para esclerosis múltiple: nueva estrategia terapéutica para la entrega directa de inmunomoduladores en el sistema central.
  • Modulation if neurogenesis by perinatal asphyxia: role of dopamine and regulators of G-proteins (GRS).
  • Long-term changes in brain neurocircuitries produced by perinatal asphyxia: is Poly (ADP-ribose) Polymerase-1 (PARP-1) Inhibition a strategy for neuroprotection?
  • Neurogénesis postnatal inducida por injurias cerebrales y su modulación por vías de señalización asociadas al factor de crecimiento de fibroblasto básico (bFGF)

Publicaciones :

  • Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats,ADDICTION BIOLOGY 2019.
  • ANTI-INFLAMMATORY MESENCHYMAL STEM CELLS AND N-ACETYL CYSTEINE INHIBIT CHRONIC ETHANOL INTAKE AND ABOLISH RELAPSE BINGE DRINKING: PRECLINICAL STUDIES,ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 2018.
  • Targeting Sentinel Proteins and Extrasynaptic Glutamate Receptors: a Therapeutic Strategy for Preventing the Effects Elicited by Perinatal Asphyxia?,NEUROTOXICITY RESEARCH 2018.
  • Regionally Impaired Redox Homeostasis in the Brain of Rats Subjected to Global Perinatal Asphyxia: Sustained Effect up to 14 Postnatal Days,NEUROTOXICITY RESEARCH 2018.
  • Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking,SCIENTIFIC REPORTS. 2018.
  • Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats: Inhibition by N-Acetylcysteine,ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 2018.
  • Gold nanorods/siRNA complex administration for knockdown of PARP-1: a potential treatment for perinatal asphyxia,INTERNATIONAL JOURNAL OF NANOMEDICINE 2018.
  • Acquisition, Maintenance and Relapse-Like Alcohol Drinking: Lessons from the UChB Rat Line,FRONTIERS IN BEHAVIORAL NEUROSCIENCE 2017.
  • Models of progressive neurological dysfunction originating  early in life,PROGRESS IN NEUROBIOLOGY 2017.
  • Modulation of Postnatal Neurogenesis by Perinatal Asphyxia: Effect of D-1 and D-2 Dopamine Receptor Agonists,NEUROTOXICITY RESEARCH 2017.
  • ALCOHOL INTAKE: FROM INITIATION TO MAINTENANCE AND RELAPSE BINGE-DRINKING. MECHANISMS AND TRANSLATIONAL OPPORTUNITIES,ALCOHOL AND ALCOHOLISM 2017.
  • Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats,ALCOHOL AND ALCOHOLISM 2017.
  • ANTI-INFLAMMATORY MESENCHYMAL STEM CELL-DERIVED SPHEROIDS INHIBIT CHRONIC AND RELAPSE-LIKE ETHANOL INTAKE AND REDUCE OXIDATIVE STRESS,ALCOHOL AND ALCOHOLISM 2017.
  • Vulnerability to a Metabolic Challenge Following Perinatal Asphyxia Evaluated by Organotypic Cultures: Neonatal Nicotinamide Treatment,NEUROTOXICITY RESEARCH 2017.
  • Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress,PHARMACOLOGY & THERAPEUTICS 2016.
  • Effects of oxidative stress induced by perinatal asphyxia on catalase activity in the hippocampus of neonatal rats,EUROPEAN NEUROPSYCHOPHARMACOLOGY 2016.
  • Effect of perinatal asphyxia on tuberomammillary nucleus neuronal density and object recognition memory: A possible role for histamine?,BEHAVIOURAL BRAIN RESEARCH 2016.
  • Short- and long-term consequences of perinatal asphyxia: Looking for neuroprotective strategies,Perinatal Programming of Neurodevelopment 2015.
  • Perinatal Asphyxia Leads to PARP-1 Overactivity, p65 Translocation, IL-1 beta and TNF-alpha Overexpression, and Apoptotic-Like Cell Death in Mesencephalon of Neonatal Rats: Prevention by Systemic Neonatal Nicotinamide Administration,NEUROTOXICITY RESEARCH 2015.
  • Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake,ALCOHOL 2015.
  • Perinatal asphyxia: CNS development and deficits with delayed onset,FRONTIERS IN NEUROSCIENCE 2014.
  • KNOCKDOWN OF HCN CHANNELS INTO THE VENTRAL TEGMENTAL AREA REDUCES ETHANOL CONSUMPTION IN UCHB DRINKING RATS,ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 2014.
  • Gene specific modifications unravel ethanol and acetaldehyde actions,FRONTIERS IN BEHAVIORAL NEUROSCIENCE 2013.
  • Further Studies on the Hypothesis of PARP-1 Inhibition as a Strategy for Lessening the Long-Term Effects Produced by Perinatal Asphyxia: Effects of Nicotinamide and Theophylline on PARP-1 Activity in Brain and Peripheral Tissue,NEUROTOXICITY RESEARCH 2012.
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