María Cecilia Hidalgo Tapia


  • Licenciada en Bioquímica ,Universidad de Chile 1965
  • Primera Doctora en Ciencias ,Universidad de Chile 1969
  • Post doctorado , National Institutes of Health, Bethesda 1969-1972
  • Staff Scientist Boston Biomedical Research Institute y Ass
  • ociate, Harvard Medical School 1977-1986

Categoría académica:

  •  Profesora Titular Instituto de Ciencias Biomédicas .
  • Profesor Titular Departamento de Neurociencia.
  • Premio Nacional de Ciencias Naturales
  • Directora del Centro FONDAP de Estudios Moleculares de la Célula
  • Directorio en sociedades científicas nacionales e internacionales ,Comisión Asesora Presidencial en Materias Científicas.
  • Academia de Ciencias de América Latina (ACAL)

Linea de Investigación :

  • Estudio de los mecanismos moleculares que son activados por aumentos transitorios de la concentración intracelular de calcio en neuronas y en el músculo esquelético y cardiaco.

Publicaciones :

  • Noxious Iron-Calcium Connections in Neurodegeneration,FRONTIERS IN NEUROSCIENCE 2019.
  • Triclosan impairs hippocampal synaptic plasticity and spatial memory in male rats,FRONTIERS IN MOLECULAR NEUROSCIENCE 2018.
  • Contextual Fear Memory Formation and Destabilization Induce Hippocampal RyR2 Calcium Channel Upregulation,NEURAL PLASTICITY 2018.
  • Mitochondrial Calcium Increase Induced by RyR1 and IP3R Channel Activation After Membrane Depolarization Regulates Skeletal Muscle Metabolism,FRONTIERS IN PHYSIOLOGY,2018.
  • N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer’s Disease Rat Model,FRONTIERS IN AGING NEUROSCIENCE 2018.
  • The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2018.
  • Ryanodine Receptor-Mediated Calcium Release Has a Key Role in Hippocampal LTD Induction,FRONTIERS IN CELLULAR NEUROSCIENCE 2018.
  • Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory,ANTIOXIDANTS & REDOX SIGNALING 2018.
  • RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid beta Peptide Oligomers,FRONTIERS IN MOLECULAR NEUROSCIENCE 2017.
  • Calcium Rules 2017.
  • Triclosan impairs hippocampal neuronal function,JOURNAL OF NEUROCHEMISTRY 2017.
  • Aging Impairs Hippocampal-Dependent Recognition Memory and LTP and Prevents the Associated RyR Up-regulation,FRONTIERS IN AGING NEUROSCIENCE 2017.
  • Mecp2 mediates experience-dependent transcriptional upregulation of ryanodine receptor type-3,FRONTIERS IN MOLECULAR NEUROSCIENCE 2017.
  • Development of an iron-selective antioxidant probe with protective effects on neuronal function,PLOS ONE 2017.
  • Membrane Cholesterol in Skeletal Muscle: A Novel Player in Excitation-Contraction Coupling and Insulin Resistance,JOURNAL OF DIABETES RESEARCH 2017.
  • Calcium, Reactive Oxygen Species, and Synaptic Plasticity 2016.
  • Glucose-Dependent Insulin Secretion in Pancreatic beta-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors,PLOS ONE 2015.
  • Cholesterol removal from adult skeletal muscle impairs excitation-contraction coupling and aging reduces caveolin-3 and alters the expression of other triadic proteins,FRONTIERS IN PHYSIOLOGY 2015.
  • Role of RyR2-mediated calcium release in synaptic plasticity, learning and memory in control and AD-model rats JOURNAL OF NEUROCHEMISTRY 2015.
  • The cholesterol-lowering agent methyl-beta-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice,AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,2015.
  • Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2+ release without affecting endoplasmic reticulum Ca2+ content in primary hippocampal neurons,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2015.
  • Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates nnitochondrial Ca2+ uptake in primary hippocampal neurons,FRONTIERS IN MOLECULAR NEUROSCIENCE 2014.
  • Insulin elicits a ROS-activated and an IP3-dependent Ca2+ release, which both impinge on GLUT4 translocation,JOURNAL OF CELL SCIENCE 2014.
  • Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca2+ uptake in primary hippocampal neurons,FRONTIERS IN MOLECULAR NEUROSCIENCE 2014.
  • Posttranslational modifications of cardiac ryanodine receptors/calcium release channels by reactive oxygen species and reactive nitrogen species,Systems Biology of Free Radicals and Antioxidants 2014.
  • Contribution of Ca2+ Release Channels to Hippocampal Synaptic Plasticity and Spatial Memory: Potential Redox Modulation ANTIOXIDANTS & REDOX SIGNALING 2014.
  • Cholesterol accumulation in skeletal muscle: a potential novel targetable pathway in insulin resistance,FASEB JOURNAL 2014.
  • Abeta oligomers and iron stimulate calcium and ROS-dependent mitochondrial fragmentation in primary hippocampal neurons,JOURNAL OF NEUROCHEMISTRY 2014.
  • Methyl-beta-cyclodextrin increases GLUT4-mediated glucose transport in skeletal muscle fibers from insulin resistant mice,2015
  • Redox-sensitive stimulation of type-1 ryanodine receptors by the scorpion toxin maurocalcine,CELL CALCIUM 2013.
  • Amyloid beta-peptide oligomers, ryanodine receptor-mediated Ca2+ release, and Wnt-5a/Ca2+ signaling: opposing roles in neuronal mitochondrial dynamics?,FRONTIERS IN CELLULAR NEUROSCIENCE 2013.
  • Cell cholesterol levels determine glucose uptake and insulin resistance in skeletal muscle,FASEB JOURNAL 2014.
  • Sub-lethal levels of amyloid beta-peptide oligomers decrease non-transferrin-bound iron uptake and do not potentiate iron toxicity in primary hippocampal neurons BIOMETALS 2012.
  • The Antioxidant N-Acetylcysteine Prevents the Mitochondrial Fragmentation Induced by Soluble Amyloid-beta Peptide Oligomers,NEURODEGENERATIVE DISEASES 2012.
  • Modulation of cardiac ryanodine receptor activity by ROS and RNS,FRONTIERS IN BIOSCIENCE-LANDMARK 2012.
  • Iron Mediates N-Methyl-D-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and Hippocampal Synaptic Plasticity,JOURNAL OF BIOLOGICAL CHEMISTRY 2011.
  • Amyloid beta-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF,ANTIOXIDANTS & REDOX SIGNALING 2011.
  • High-Frequency Field Stimulation of Primary Neurons Enhances Ryanodine Receptor-Mediated Ca2+ Release and Generates Hydrogen Peroxide, Which Jointly Stimulate NF-kappa B Activity,ANTIOXIDANTS & REDOX SIGNALING 2011.
  • Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2011.
  • Getting to the Heart of Mechanotransduction,SCIENCE 2011.
  • Redox Control of Brain Calcium in Health and Disease,ANTIOXIDANTS & REDOX SIGNALING 2011.
  • H2O2 Production and Glutathionylation of Ryanodine Receptor in Skeletal Muscle from Insulin Resistance Mice,FREE RADICAL BIOLOGY AND MEDICINE 2010.
  • Increased Hippocampal Expression of the Divalent Metal Transporter 1 (DMT1) mRNA Variants 1B and +IRE and DMT1 Protein After NMDA-Receptor Stimulation or Spatial Memory Training,NEUROTOXICITY RESEARCH 2010.
  • Parallel activation of Ca2+-induced survival and death pathways in cardiomyocytes by sorbitol-induced hyperosmotic stress,APOPTOSIS 2010.
  • Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion,BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2010.
  • The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2009.
  • NADPH Oxidase and Hydrogen Peroxide Mediate Insulin-induced Calcium Increase in Skeletal Muscle Cells,JOURNAL OF BIOLOGICAL CHEMISTRY 2009.