Licenciada en Bioquímica ,Universidad de Chile 1965
Primera Doctora en Ciencias ,Universidad de Chile 1969
Post doctorado , National Institutes of Health, Bethesda 1969-1972
Staff Scientist Boston Biomedical Research Institute y Ass
ociate, Harvard Medical School 1977-1986
Categoría académica:
Profesora Titular Instituto de Ciencias Biomédicas .
Profesor Titular Departamento de Neurociencia.
Premio Nacional de Ciencias Naturales
Directora del Centro FONDAP de Estudios Moleculares de la Célula
Directorio en sociedades científicas nacionales e internacionales ,Comisión Asesora Presidencial en Materias Científicas.
Academia de Ciencias de América Latina (ACAL)
Linea de Investigación :
Estudio de los mecanismos moleculares que son activados por aumentos transitorios de la concentración intracelular de calcio en neuronas y en el músculo esquelético y cardiaco.
Noxious Iron-Calcium Connections in Neurodegeneration,FRONTIERS IN NEUROSCIENCE 2019.
Triclosan impairs hippocampal synaptic plasticity and spatial memory in male rats,FRONTIERS IN MOLECULAR NEUROSCIENCE 2018.
Contextual Fear Memory Formation and Destabilization Induce Hippocampal RyR2 Calcium Channel Upregulation,NEURAL PLASTICITY 2018.
Mitochondrial Calcium Increase Induced by RyR1 and IP3R Channel Activation After Membrane Depolarization Regulates Skeletal Muscle Metabolism,FRONTIERS IN PHYSIOLOGY,2018.
N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer’s Disease Rat Model,FRONTIERS IN AGING NEUROSCIENCE 2018.
The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2018.
Ryanodine Receptor-Mediated Calcium Release Has a Key Role in Hippocampal LTD Induction,FRONTIERS IN CELLULAR NEUROSCIENCE 2018.
Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory,ANTIOXIDANTS & REDOX SIGNALING 2018.
RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid beta Peptide Oligomers,FRONTIERS IN MOLECULAR NEUROSCIENCE 2017.
Calcium Rules 2017.
Triclosan impairs hippocampal neuronal function,JOURNAL OF NEUROCHEMISTRY 2017.
Aging Impairs Hippocampal-Dependent Recognition Memory and LTP and Prevents the Associated RyR Up-regulation,FRONTIERS IN AGING NEUROSCIENCE 2017.
Mecp2 mediates experience-dependent transcriptional upregulation of ryanodine receptor type-3,FRONTIERS IN MOLECULAR NEUROSCIENCE 2017.
Development of an iron-selective antioxidant probe with protective effects on neuronal function,PLOS ONE 2017.
Membrane Cholesterol in Skeletal Muscle: A Novel Player in Excitation-Contraction Coupling and Insulin Resistance,JOURNAL OF DIABETES RESEARCH 2017.
ATP-BINDING CASSETTE TRANSPORTER ABCA1 IS DECREASED IN SKELETAL MUSCLE FROM INSULIN RESISTANT MICE,FASEB JOURNAL 2017.
EXCITATION-METABOLISM COUPLING: ROLE OF MEMBRANE DEPOLARIZATION ON THE MITOCHONDRIAL FUNCTION,FASEB JOURNAL 2016.
EXCITATION-METABOLISM COUPLING: ROLE OF MEMBRANE DEPOLARIZATION ON THE MITOCHONDRIAL FUNCTION,FASEB JOURNAL 2016.
Calcium, Reactive Oxygen Species, and Synaptic Plasticity 2016.
Glucose-Dependent Insulin Secretion in Pancreatic beta-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors,PLOS ONE 2015.
Cholesterol removal from adult skeletal muscle impairs excitation-contraction coupling and aging reduces caveolin-3 and alters the expression of other triadic proteins,FRONTIERS IN PHYSIOLOGY 2015.
Role of RyR2-mediated calcium release in synaptic plasticity, learning and memory in control and AD-model rats JOURNAL OF NEUROCHEMISTRY 2015.
The cholesterol-lowering agent methyl-beta-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice,AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,2015.
Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2+ release without affecting endoplasmic reticulum Ca2+ content in primary hippocampal neurons,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2015.
Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates nnitochondrial Ca2+ uptake in primary hippocampal neurons,FRONTIERS IN MOLECULAR NEUROSCIENCE 2014.
Insulin elicits a ROS-activated and an IP3-dependent Ca2+ release, which both impinge on GLUT4 translocation,JOURNAL OF CELL SCIENCE 2014.
Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca2+ uptake in primary hippocampal neurons,FRONTIERS IN MOLECULAR NEUROSCIENCE 2014.
Posttranslational modifications of cardiac ryanodine receptors/calcium release channels by reactive oxygen species and reactive nitrogen species,Systems Biology of Free Radicals and Antioxidants 2014.
Contribution of Ca2+ Release Channels to Hippocampal Synaptic Plasticity and Spatial Memory: Potential Redox Modulation ANTIOXIDANTS & REDOX SIGNALING 2014.
Cholesterol accumulation in skeletal muscle: a potential novel targetable pathway in insulin resistance,FASEB JOURNAL 2014.
Abeta oligomers and iron stimulate calcium and ROS-dependent mitochondrial fragmentation in primary hippocampal neurons,JOURNAL OF NEUROCHEMISTRY 2014.
Methyl-beta-cyclodextrin increases GLUT4-mediated glucose transport in skeletal muscle fibers from insulin resistant mice,2015
Redox-sensitive stimulation of type-1 ryanodine receptors by the scorpion toxin maurocalcine,CELL CALCIUM 2013.
Amyloid beta-peptide oligomers, ryanodine receptor-mediated Ca2+ release, and Wnt-5a/Ca2+ signaling: opposing roles in neuronal mitochondrial dynamics?,FRONTIERS IN CELLULAR NEUROSCIENCE 2013.
Cell cholesterol levels determine glucose uptake and insulin resistance in skeletal muscle,FASEB JOURNAL 2014.
Sub-lethal levels of amyloid beta-peptide oligomers decrease non-transferrin-bound iron uptake and do not potentiate iron toxicity in primary hippocampal neurons BIOMETALS 2012.
The Antioxidant N-Acetylcysteine Prevents the Mitochondrial Fragmentation Induced by Soluble Amyloid-beta Peptide Oligomers,NEURODEGENERATIVE DISEASES 2012.
Modulation of cardiac ryanodine receptor activity by ROS and RNS,FRONTIERS IN BIOSCIENCE-LANDMARK 2012.
Iron Mediates N-Methyl-D-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and Hippocampal Synaptic Plasticity,JOURNAL OF BIOLOGICAL CHEMISTRY 2011.
Amyloid beta-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF,ANTIOXIDANTS & REDOX SIGNALING 2011.
High-Frequency Field Stimulation of Primary Neurons Enhances Ryanodine Receptor-Mediated Ca2+ Release and Generates Hydrogen Peroxide, Which Jointly Stimulate NF-kappa B Activity,ANTIOXIDANTS & REDOX SIGNALING 2011.
Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2011.
Getting to the Heart of Mechanotransduction,SCIENCE 2011.
Redox Control of Brain Calcium in Health and Disease,ANTIOXIDANTS & REDOX SIGNALING 2011.
H2O2 Production and Glutathionylation of Ryanodine Receptor in Skeletal Muscle from Insulin Resistance Mice,FREE RADICAL BIOLOGY AND MEDICINE 2010.
Increased Hippocampal Expression of the Divalent Metal Transporter 1 (DMT1) mRNA Variants 1B and +IRE and DMT1 Protein After NMDA-Receptor Stimulation or Spatial Memory Training,NEUROTOXICITY RESEARCH 2010.
Parallel activation of Ca2+-induced survival and death pathways in cardiomyocytes by sorbitol-induced hyperosmotic stress,APOPTOSIS 2010.
Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion,BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2010.
The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2009.
NADPH Oxidase and Hydrogen Peroxide Mediate Insulin-induced Calcium Increase in Skeletal Muscle Cells,JOURNAL OF BIOLOGICAL CHEMISTRY 2009.