Académico(a):

Jimena Alejandra Sierralta Jara

jsierral@uchile.cl

Formación:

  • Doctora en Ciencias,Universidad de Chile, 1996.
  • Bioquímica, Pontificia Universidad Católica de Chile, 1988.

Categoría académica:

  • Profesora Titular Departamento de Neurociencias, Facultad de Medicina Universidad de Chile
  • Directora del Departamento de Neurociencia,Facultad de Medicina Universidad de Chile

Linea de Investigación

  • Anillo de Drosophila en Adaptaciones al Estrés Nutricional en el Desarrollo DRiDANS.
  • Role of the putative monocarboxilate transporter CG3409 (chaski) on the adaptive response of Drosophila melanogaster to nutritional restriction during development.
  • Role of drosophila dig in synaptic plasticity.

Financiamiento actual y terminados los últimos 5 años:

2020-2024 FONDECYT Regular Grant Nº 1210586. Principal Investigator: Energy metabolism at the synapse: unraveling the role of glial derived lactate to sustain high activity transmission in vivo.

2017-2020 FONDECYT Regular Grant Nº 1171800. Principal Investigator: Presynaptic calcium signal in glutamatergic synapses: role of scaffold proteins in its modulation.

2016-2021Millenium Initiative ICM P09015F, Biomedical Neuroscience Institute, Principal Investigator

2015-2018 Anillo de Ciencia y Tecnología PIA ACT 1401, Main Researcher: Drosophila Ring in Developmental Adaptations to Nutritional Stress (DRiDANS)

 

Publications and Book chapters last 5 years

| # Corresponding author

 

  1. González-Gutiérrez A#, Gaete J, Esparza A, Toledo J, Köhler-Solis A, Sierralta J#. Visualizing Monocarboxylates and Other Relevant Metabolites in the Ex Vivo Drosophila Larval Brain Using Genetically Encoded Sensors. J Vis Exp. 2023 Oct 27;(200). doi: 10.3791/65846.

 

  1. Xu D, Vincent A, González-Gutiérrez A, Aleyakpo B, Anoar S, Giblin A, Atilano ML, Adams M, Shen D, Thoeng A, Tsintzas E, Maeland M, Isaacs AM, Sierralta J, Niccoli T#. A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer’s disease models. PLoS Genet. 2023 Sep 21;19(9):e1010893. doi: 10.1371/ journal. pgen. 1010893.

 

  1. Bertin F, Jara-Wilde J, Auer B, Köhler-Solís A, González-Silva C, Thomas U, Sierralta J#. Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling. Biol Res. 2023 Sep 14;56(1):49. doi: 10.1186/s40659-023-00462-1.

 

  1. Candia N, Ibacache A, Medina-Yáñez I, Olivares GH, Ramírez M, Vega-Macaya F, Couve A, Sierralta J, Olguín P#. Identification of atlastin genetic modifiers in a model of hereditary spastic paraplegia in Drosophila. Hum Genet. 2023 Aug;142(8):1303-1315. doi: 10.1007/s00439-023-02577-7. Epub 2023 Jun 27.

 

  1. Contreras EG , Sierralta J#. The Fly Blood-Brain Barrier fights against nutritional stress. Neuroscience Insight 2022;17: 26331055221120252. Published online 2022 Aug 19. doi: 10.1177/26331055221120252.

 

  1. Bertin F, Moya-Alvarado G, Quiroz-Manríquez E, Ibacache A, Köhler-Solis A, Oliva C, Sierralta J#. Dlg Is Required for Short-Term Memory and Interacts with NMDAR in the DrosophilaInt J Mol Sci. 2022;23(16):9187. Published 2022 Aug 16. doi:10.3390/ijms23169187

 

  1. Medel V#, Crossley N, Gajardo I, Muller E,  Barros LF, Shine JM#, and Sierralta J#. Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function. Proc Natl Acad Sci U S A. 2022 Aug 16; 119(33): e2204619119. Published online 2022 Aug 8. doi: 10.1073/pnas.2204619119

 

  1. Fernandez MP, Rittschof CC, Sierralta J#. Editorial: Invertebrate Neuroscience: Contributions From Model and Non-model Species. Front Behav Neurosci. 2021 Jul 14;15:726295. doi: 10.3389/fnbeh.2021.

 

  1. Contreras EG#, Glavic A, Sierralta J#. The serine protease homologue, Scarface, is sensitive to nutrient availability and modulates the development of the Drosophila blood brain barrier. J Neurosci. 2021 Jul 28;41(30):6430-6448. doi: 10.1523/JNeurosci.0452-20.2021.

 

  1. Guzmán-Palma P, Contreras EG, Mora N, Smith M, González-Ramírez MC, Campusano JM, Sierralta J, Hassan BA, Oliva C#. Slit/Robo Signaling Regulates Multiple Stages of the Development of the Drosophila Motion Detection System. Front Cell Dev Biol. 2021 Apr 21;9:612645. doi: 10.3389/fcell.2021.612645. eCollection 2021.

 

  1. González-Gutiérrez, A., Ibacache, A., Esparza, A, Barros, LF, Sierralta, J#. Neuronal lactate levels depend on glia-derived lactate during high brain activity in Drosophila. Glia 2020, Jun;68(6):1213-1227.DOI: 10.1002/glia.23772 IF: 5.829.

 

  1. Caipo L, González-Ramírez MC, Guzmán-Palma P, Contreras EG, Palominos T, Fuenzalida-Uribe N, Hassan BA, Campusano JM, Sierralta J, Oliva C#. Slit neuronal secretion coordinates optic lobe morphogenesis in Drosophila. Dev Biol. 2020 Oct 10. pii: S0012-1606(19)30198-8. doi: 10.1016/j.ydbio.2019.10.004. IF 2.936

 

  1. Contreras EG,Sierralta J#, Oliva, C#. Novel Strategies for the Generation of Neuronal Diversity: Lessons from the Fly Visual System. Front Mol Neurosci. 2019 May 31;12:140. doi: 10.3389/fnmol.2019.00140. eCollection 2019. Review. IF 3.72

 

Publicaciones:

  • Chaski, a novel Drosophila lactate/pyruvate transporter required in glia cells for survival under nutritional stress,SCIENTIFIC REPORTS 2018.
  • The transcription factor SoxD controls neuronal guidance in the Drosophila visual system,SCIENTIFIC REPORTS 2018.
  • p53 is required for brain growth but is dispensable for resistance to nutrient restriction during Drosophila larval development,PLOS ONE 2018.
  • Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1 alpha ,MOLECULAR CELL 2018.
  • Drosophila Atlastin in motor neurons is required for locomotion and presynaptic function,JOURNAL OF CELL SCIENCE 2017.
  • Presynaptic DLG regulates synaptic function through the localization of voltage-activated Ca2+ Channels,SCIENTIFIC REPORTS 2016.
  • Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex,DEVELOPMENTAL CELL 2016.
  • Hindsight regulates photoreceptor axon targeting through transcriptional control of jitterbug/Filamin and multiple genes involved in axon guidance in Drosophila,DEVELOPMENTAL NEUROBIOLOGY 2015.
  • The Specification of Cortical Subcerebral Projection Neurons Depends on the Direct Repression of TBR1 by CTIP1/BCL11a,JOURNAL OF NEUROSCIENCE 2015.
  • How doth the little busy bee: unexpected metabolism,
    TRENDS IN NEUROSCIENCES

    2015

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