Académico(a):

Carolina Andrea Delgado Derio

cdelgado@uchile.cl

Formación:

  • Médico Cirujano, Universidad de Chile 2000
  • Especialidad médica Neuróloga ,Universidad de Chile 2004.
  • Magister en Neurociencias 2011

Categoría académica:

  • Profesor Asociado Centro de Diagnóstico Hospital Clínico
  • Profesor Asociado Departamento de Neurología y Neurocirugía Norte Facultad de Medicina Universidad de Chile, Unidad Cerebro Saludable
  • Profesor Asociado Departamento de Neurociencias Facultad de Medicina

Lineas de Investigación 

  • Alteraciones cognitivas y neuropsiquiátricas en adultos.
  • Enfermedad cerebrovascular,
  • Epidemiología de los factores de riesgo
  • Promoción de envejecimiento saludable 
  • Uso de mhealth en la promoción de salud.

Proyectos de investigación de los últimos 5 años.

FONDECYT 1220607 (2023-2025)

Auditory efferent coticofugal oscillatory modulation of cochlear and auditory nerve responses in tinnitus perception: a basic and clinical approach”

PI Paul Delano

Investigadora asociada.

 

FONDEF IDEA 2021 (2021-2023) 

ID ID21I10096

M@yores app: software para fomentar la práctica de una vida saludable en el adulto mayor

PI Carolina Delgado. 

 

LatAm FINGERS – ChilE (2020-2022).

Id: SG-21-815077

PREVENCIÓN MULTIDOMINIO EN DEMENCIAS PROYECTO LATAM FINGERS

Hospital Clínico Universidad de Chile 

Fondos Alzheimer Association international

PI: Carolina Delgado

 

FONDEF IDEA 2020 (2020-2022)

ID ID20i10371

Test audiológico detecta en forma precoz la presencia de deterioro cognitivo en

adultos mayores

PI Gonzalo Farias

Investigadora asociada.

 

Anillo Año 2014 (2014-2018) Id ACP1403. 

Tittle:  From presbycusis to dementia: a basic and clinical approach”.

Investigadores principales: Carolina Delgado,  Dr. Paul Délano de la facultad de medicina U de Chile y Dr. Alexies Dagnino de la U de Valparaiso.

Publicaciones :

    1. Medel V, Delano PH, Belkhiria C, Leiva A, De Gatica C, Vidal V, Navarro CF, Martín SS, Martínez M, Gierke C, García X, Cerda M, Vergara R, Delgado C, Farías GA. Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss. Alzheimers Dement (Amst). 2024 Feb 1;16(1):e12467. doi: 10.1002/dad2.12467. PMID: 38312514; PMCID: PMC10835081.
    1. Maass JC, Leiva A, Torrente M, Vergara R, Belkhiria C, Delgado C, Delano PH. Supra-Threshold LS CE-Chirp Auditory Brainstem Response in the Elderly. Audiol Neurootol. 2024 Mar 4:1-10. doi: 10.1159/000533683. Epub ahead of print. PMID: 38437806.
    1. Natalia Pozo, César Romero, Maricarmen Andrade, Paul H. Délano, Vicente Medel, Marco Troncoso, Patricia Orellana, Maria Isabel Rodriguez, Camila Fabres, Carolina Delgado.  Exploring the relationship between frailty and executive dysfunction: the role of frontal white matter  hyperintensities.Frontiers in Aging Neuroscience, August 2023.DOI 10.3389/fnagi.2023.1196641.
    2. Gutiérrez M, Mauro J, Asecio J,Acevedo F,Herrada J,Torres C,Delgado C, Fasce G.Implementación de una jornada virtual de telesalud y capacitación masiva para personas mayores chilenas y estudiantes de la salud. Impacto en la cobertura. Revista médica de Chile, 151(1), 61-71. https://dx.doi.org/10.4067/s0034-98872023000100061.
    3. Alentorn A, Berzero G, Alexopoulos H, Tzartos J, Reyes Botero G, Morales Martínez A, Muñiz-Castrillo S, Vogrig A, Joubert B, García Jiménez FA, et al. Spatial and Ecological Factors Modulate the Incidence of Anti-NMDAR Encephalitis—A Systematic Review. Biomedicines. 2023; 11(6):1525. https://doi.org/10.3390/biomedicines11061525
    4. Crivelli L, Calandri IL, Suemoto CK, Salinas RM, Velilla LM, Yassuda MS, et al. Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS): Study design and harmonization. Alzheimer’s & dementia : the journal of the Alzheimer’s Association, 10.1002/alz.13101. Advance online publication. https://doi.org/10.1002/alz.13101
    5. Vicencio-Jimenez, S.; Delano, P.H.; Madrid, N.; Terreros, G.; Maass, J.C.; Delgado, C.; Jorratt, P. Maintained Spatial Learning and Memory Functions in Middle-Aged α9 Nicotinic Receptor Subunit Knock-Out Mice. Brain Sci. 202313, 794. https://doi.org/10.3390/brainsci13050794.
    6. Tamblay N, Boggs D, Huidobro B, Tapia-Mora D, Anabalon K, Delgado C, Polack S, Bright T, Torrente MC. Prevalence of Cognitive Impairment and Its Association With Hearing Loss Among Adults Over 50 Years of Age: Results From a Population-Based Survey in Santiago, Chile. Am J Audiol. 2023 Mar;32(1):150-159. doi: 10.1044/2022_AJA-22-00042.
    1. Grandi, Fabrissio et al. Standardization and diagnostic utility of the Frontal Assessment Battery for healthy people and patients with dementia in the Chilean population. Dementia & Neuropsychologia [online]. 2022, v. 16, n. 1 [Accessed 25 April 2022] , pp. 69-78. Epub 11 Apr 2022. ISSN 1980-5764. https://doi.org/10.1590/1980-5764-DN-2021-0059.
    1. Montesinos R, Parodi JF, Diaz MM, et al. Validation of Picture Free and Cued Selective Reminding Test for Illiteracy in Lima, Peru. American Journal of Alzheimer’s Disease & Other Dementias®. January 2022. doi:10.1177/15333175221094396
    1. Torrente MC, Vergara R, Moreno-Gómez FN, Leiva A, San Martin S, Belkhiria C, Marcenaro B, Delgado C, Delano PH. Speech Perception and Dichotic Listening Are Associated With Hearing Thresholds and Cognition, Respectively, in Unaided Presbycusis. Front Aging Neurosci. 2022;14:786330. doi: 10.3389/fnagi.2022.786330. eCollection 2022. PubMed PMID: 35283747; PubMed Central PMCID: PMC8908240.
    1. Vergara RC, Zitko P, Slachevsky A, San Martin C, Delgado C. Population attributable fraction of modifiable risk factors for dementia in Chile. Alzheimers Dement (Amst). 2022;14(1):e12273. doi: 10.1002/dad2.12273. eCollection 2022. PubMed PMID: 35229017; PubMed Central PMCID: PMC8864720.
    2. Acevedo P., Fabrizio, Delgado Derio, Carolina, & Farías, Gonzalo. (2021). Estrategias no farmacológicas en personas con Demencia Avanzada: reporte de un caso.. Revista chilena de neuro-psiquiatría59(4), 368-374. https://dx.doi.org/10.4067/S0717-92272021000400368
    1. Belkhiria C, Vergara RC, Martinez M, Delano PH, Delgado C. Neural links between facial emotion recognition and cognitive impairment in presbycusis. Int J Geriatr Psychiatry. 2021 Jan 27. doi: 10.1002/gps.5501. Epub ahead of print. PMID: 33503682
    1. Arévalo NB, Castillo-Godoy DP, Espinoza-Fuenzalida I, Rogers NK, Farias G, Delgado C, Henriquez M, Herrera L, Behrens MI, SanMartín CD. Association of Vitamin D Receptor Polymorphisms with Amyloid-β Transporters Expression and Risk of Mild Cognitive Impairment in a Chilean Cohort. J Alzheimers Dis. 2020 Nov 13. doi: 10.3233/JAD-201031. Epub ahead of print. PMID: 33216035.
    1. Burgos PI, Lara O, Lavado A, Rojas-Sepúlveda I, Delgado C, Bravo E, Kamisato C, Torres J, Castañeda V, Cerda M. Exergames and Telerehabilitation on Smartphones to Improve Balance in Stroke Patients. Brain Sci. 2020 Oct 23;10(11):E773. doi: 10.3390/brainsci10110773. PMID: 33114245.
    1. Wimmer J, Delgado C,  Torrente MC,  Délano P H. Hipoacusia como factor de riesgo para demencia. Rev Med Chile 2020; 148: 1128-1138.http://dx.doi.org/10.4067/S0034-98872020000801128.
    1. Delano PH, Belkhiria C, Vergara RC, Martínez M, Leiva A, Andrade M, Marcenaro B, Torrente M, Maass JC, Delgado C. Reduced suprathreshold auditory nerve responses are associated with slower processing speed and thinner temporal and parietal cortex in presbycusis. PONE-D-20-04256R1 https://doi.org/10.1371/journal.pone.0233224
    1. Belkhiria C, Vergara RC, San Martin S, Leiva A, Martinez M, Marcenaro B, Andrade M, Delano PH, Delgado C Insula and Amygdala Atrophy Are Associated With Functional Impairment in Subjects With Presbycusis. Front. Aging Neurosci., 28 April 2020 | https://doi.org/10.3389/fnagi.2020.00102
    1. Belkhiria C, Vergara RC, San Martín S, Leiva A, Marcenaro B, Martinez M, Delgado C, Delano PH.  Cingulate Cortex Atrophy Is Associated with Hearing Loss In Presbycusis With Cochlear Amplifier Dysfunction. Front. Aging Neurosci. (2019) doi: 10.3389/fnagi.2019.00097
    1. Slachevsky A, Forno G, Barraza P, Mioshi E, Delgado C, Lillo P, Henriquez F, Bravo E, Farias M, Muñoz-Neira C, Ibañez A, Parra MA, Hornberger. Mapping the neuroanatomy of functional decline in Alzheimer’s disease from basic to advanced activities of daily living. Journal of Neurology (2019).  https://doi.org/10.1007/s00415-019-09260-w
    1. Delgado C, Vergara RC, Martínez M, Musa G, Henríquez F, Slachevsky A.  Neuropsychiatric Symptoms in Alzheimer’s Disease Are the Main Determinants of Functional Impairment in Advanced Everyday Activities.  Journal of Alzheimer’s Disease 67 (2019) 381–392.  DOI 10.3233/JAD-180771
    1. Pavez R., Axel, Delgado D., Carolina, & Martínez S., Melissa. Memory complaints in behavioral variant frontotemporal dementia: a case report. Revista chilena de neuro-psiquiatría, (2018).  56(1), 57-63. https://dx.doi.org/10.4067/s0717-92272018000100057 
    2. Collao-Parra, Juan Pablo, Romero-Urra, César, & Delgado-Derio, Carolina. Encefalitis autoinmunes: criterios diagnósticos y pautas terapéuticas. Revista médica de Chile, (2018). 146(3), 351-361. https://dx.doi.org/10.4067/s0034-98872018000300351
    1. Bertoux M, Flanagan EC, Hobbs M, Ruiz-Tagle A, Delgado C, Miranda M, Ibáñez A, Slachevsky A, Hornberger M. Structural Anatomical Investigation of Long-Term Memory Deficit in Behavioral Frontotemporal Dementia. J Alzheimers Dis. (2018);62(4):1887-1900. doi: 10.3233/JAD-170771.

    Slachevsky A, Barraza P, Hornberger M, Muñoz-Neira C, Flanagan E, Henríquez F, Bravo E, Farías M, Delgado C. Neuroanatomical Comparison of the «Word» and «Picture» Versions of the Free and Cued Selective Reminding Test in Alzheimer’s Disease. J Alzheimers Dis. (2018);61(2):589-600. doi: 10.3233/JAD-160973

  • Cingulate Cortex Atrophy Is Associated With Hearing Loss in Presbycusis With Cochlear Amplifier Dysfunction,FRONTIERS IN AGING NEUROSCIENCE 2019.
  • Mapping the neuroanatomy of functional decline in Alzheimer’s disease from basic to advanced activities of daily living,JOURNAL OF NEUROLOGY 2019.
  • Neuropsychiatric Symptoms in Alzheimer’s Disease Are the Main Determinants of Functional Impairment in Advanced Everyday Activities,JOURNAL OF ALZHEIMERS DISEASE 2019.
  • Autoimmune encephalitis. A review,REVISTA MEDICA DE CHILE 2018.
  • Memory complaints in behavioral variant frontotemporal dementia: a case report,REVISTA CHILENA DE NEURO-PSIQUIATRIA 2019.
  • Structural Anatomical Investigation of Long-Term Memory Deficit in Behavioral Frontotemporal Dementia,JOURNAL OF ALZHEIMERS DISEASE 2019.
  • Neuroanatomical Comparison of the «Word» and «Picture» Versions of the Free and Cued Selective Reminding Test in Alzheimer’s Disease,JOURNAL OF ALZHEIMERS DISEASE 2018.
  • Frailty Phenotype and Cognitive Status in Chilean Community – Dwelling Older Adults without Dementia,JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 2018.
  • Music Training and Education Slow the Deterioration of Music Perception Produced by Presbycusis in the Elderly,FRONTIERS IN AGING NEUROSCIENCE,2017.
  • Utility of the neuropsychiatric inventory questionnaire (NPI-Q) in the assessment of a sample of patients with Alzheimer¿s disease in Chile,DEMENTIA E NEUROPSYCHOLOGIA 2017.
  • Difference in Perseverative Errors during a Visual Attention Task with Auditory Distractors in Alpha-9 Nicotinic Receptor Subunit Wild Type and Knock-Out Mice,FRONTIERS IN CELLULAR NEUROSCIENCE 2017.
  • The cost of dementia in an unequal country: The case of Chile,PLOS ONE 2017.
  • Tau Platelets Correlate with Regional Brain Atrophy in Patients with Alzheimer’s Disease,JOURNAL OF ALZHEIMERS DISEASE 2017.
  • Comparison of the Psychometric Properties of the «Word» and «Picture» Versions of the Free and Cued Selective Reminding Test in a Spanish-Speaking Cohort of Patients with Mild Alzheimer’s Disease and Cognitively Healthy Controls,ARCHIVES OF CLINICAL NEUROPSYCHOLOGY 2016.
  • Chilean Healthcare Professionals’ Perception of Knowledge about Dementia,REVISTA MEDICA DE CHILE 2016.
  • So close yet so far: executive contribution to memory processing in behavioural variant frontotemporal dementia,JOURNAL OF NEUROCHEMISTRY 2016.
  • So Close Yet So Far: Executive Contribution to Memory Processing in Behavioral Variant Frontotemporal Dementia,JOURNAL OF ALZHEIMERS DISEASE 2016.
  • Cognitive and functional impairment: Correlative and predictive analyses across a sample made up of patients with dementia, MCI and controls,JOURNAL OF THE NEUROLOGICAL SCIENCES 2015.
  • Functional correlates of the technology-activities of daily living questionnaire in alzheimer’s diseases,JOURNAL OF THE NEUROLOGICAL SCIENCES 2015.
  • Anatomical correlations of memory impairment measured by the free and cued selective remanding test verbal and visual versions,JOURNAL OF THE NEUROLOGICAL SCIENCES 2015.
  • Chilean health professionals perception of knowledge about dementia,JOURNAL OF THE NEUROLOGICAL SCIENCES 2015.
  • Test Your MemorySpanish version (TYM-S): a validation study of a self-administered cognitive screening test,INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY 2015.
  • Nutraceuticals: A Novel Concept in Prevention and Treatment of Alzheimer’s Disease and Related Disorders,JOURNAL OF ALZHEIMERS DISEASE 2014.
  • Memory, fluency, and orientation: A five-minute screening test for cognitive decline,NEUROLOGIA 2013.
  • The CUIDEME Study: Determinants of Burden in Chilean Primary Caregivers of Patients with Dementia,JOURNAL OF ALZHEIMERS DISEASE 2013.
  • Personality Disorder Related To an Acute Orbitofrontal Lesion in Multiple Sclerosis,JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES 2011.
  • Frequency and Determinants of Poststroke Cognitive Impairment at Three and Twelve Months in Chile,DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 2010.
  • Posterior cortical atrophy. Report of five cases,REVISTA MEDICA DE CHILE 2009.
  • HYPOACTIVE DELIRIUM IN SEPTIC MECHANICALLY VENTILATED PATIENT. PRELIMINARY DATA OF COGNITIVE AND PSYCHIATRIC FOLLOW UP,CRITICAL CARE MEDICINE 2009.
  • Prevention and treatment of Alzheimer disease,REVISTA MEDICA DE CHILE 2009.
  • Cognitive performance in patients with coronary heart disease and cardiovascular risk factors in Chile,REVISTA DE NEUROLOGIA 2008.
  • Thrombotic thrombocytopenic purpura with neurological involvement. Report of one case,REVISTA MEDICA DE CHILE 2008.
Comparte: